The SNARE Machinery in Mast Cell Secretion

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2012 Jun 9

PMID 22679448

Citations 53

Authors

Axel Lorentz

Anja Baumann

Joana Vitte

Ulrich Blank

Affiliations

Soon will be listed here.

Abstract

Mast cells are known as inflammatory cells which exert their functions in allergic and anaphylactic reactions by secretion of numerous inflammatory mediators. During an allergic response, the high-affinity IgE receptor, FcεRI, becomes cross-linked by receptor-bound IgE and antigen resulting in immediate release of pre-synthesized mediators - stored in granules - as well as in de novo synthesis of various mediators like cytokines and chemokines. Soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptors (SNARE) proteins were found to play a central role in regulating membrane fusion events during exocytosis. In addition, several accessory regulators like Munc13, Munc18, Rab GTPases, secretory carrier membrane proteins, complexins, or synaptotagmins were found to be involved in membrane fusion. In this review we summarize our current knowledge about the SNARE machinery and its mechanism of action in mast cell secretion.

Citing Articles

CREB Is Critically Implicated in Skin Mast Cell Degranulation Elicited via FcεRI and MRGPRX2.

Li Z, Schneikert J, Tripathi S, Jin M, Bal G, Zuberbier T Cells. 2024; 13(20.

PMID: 39451199 PMC: 11506305. DOI: 10.3390/cells13201681.

Anaphylactic degranulation by mast cells requires the mobilization of inflammasome components.

Mencarelli A, Bist P, Choi H, Khameneh H, Mortellaro A, Abraham S Nat Immunol. 2024; 25(4):693-702.

PMID: 38486019 DOI: 10.1038/s41590-024-01788-y.

Genetic analysis of potential biomarkers and therapeutic targets in neuroinflammation from sporadic Creutzfeldt-Jakob disease.

Cheng Y, Chen T, Hu J Sci Rep. 2023; 13(1):14122.

PMID: 37644077 PMC: 10465546. DOI: 10.1038/s41598-023-41066-9.

Potential Role of Moesin in Regulating Mast Cell Secretion.

Theoharides T, Kempuraj D Int J Mol Sci. 2023; 24(15).

PMID: 37569454 PMC: 10418457. DOI: 10.3390/ijms241512081.

Mycolactone: A Broad Spectrum Multitarget Antiviral Active in the Picomolar Range for COVID-19 Prevention and Cure.

Asiedu S, Gupta Y, Nicolaescu V, Gula H, Caulfield T, Durvasula R Int J Mol Sci. 2023; 24(8).

PMID: 37108313 PMC: 10139166. DOI: 10.3390/ijms24087151.

References

Feldmann J, Callebaut I, Raposo G, Certain S, Bacq D, Dumont C . Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3). Cell. 2003; 115(4):461-73. DOI: 10.1016/s0092-8674(03)00855-9. View

Murray R, Kay J, Sangermani D, Stow J . A role for the phagosome in cytokine secretion. Science. 2005; 310(5753):1492-5. DOI: 10.1126/science.1120225. View

Behrendorff N, Dolai S, Hong W, Gaisano H, Thorn P . Vesicle-associated membrane protein 8 (VAMP8) is a SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) selectively required for sequential granule-to-granule fusion. J Biol Chem. 2011; 286(34):29627-34. PMC: 3283193. DOI: 10.1074/jbc.M111.265199. View

Ono S, Baux G, Sekiguchi M, Fossier P, Morel N, Nihonmatsu I . Regulatory roles of complexins in neurotransmitter release from mature presynaptic nerve terminals. Eur J Neurosci. 1998; 10(6):2143-52. DOI: 10.1046/j.1460-9568.1998.00225.x. View

Coppola T, Perret-Menoud V, Gattesco S, Magnin S, Pombo I, Blank U . The death domain of Rab3 guanine nucleotide exchange protein in GDP/GTP exchange activity in living cells. Biochem J. 2002; 362(Pt 2):273-9. PMC: 1222386. DOI: 10.1042/0264-6021:3620273. View

Dascher C, Ossig R, Gallwitz D, Schmitt H . Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily. Mol Cell Biol. 1991; 11(2):872-85. PMC: 359739. DOI: 10.1128/mcb.11.2.872-885.1991. View

Qiao H, Andrade M, Lisboa F, Morgan K, Beaven M . FcepsilonR1 and toll-like receptors mediate synergistic signals to markedly augment production of inflammatory cytokines in murine mast cells. Blood. 2005; 107(2):610-8. PMC: 1895616. DOI: 10.1182/blood-2005-06-2271. View

Huse M, Quann E, Davis M . Shouts, whispers and the kiss of death: directional secretion in T cells. Nat Immunol. 2008; 9(10):1105-11. PMC: 2905669. DOI: 10.1038/ni.f.215. View

Lacy P, Stow J . Cytokine release from innate immune cells: association with diverse membrane trafficking pathways. Blood. 2011; 118(1):9-18. DOI: 10.1182/blood-2010-08-265892. View

10.

Reim K, Mansour M, Varoqueaux F, McMahon H, Sudhof T, Brose N . Complexins regulate a late step in Ca2+-dependent neurotransmitter release. Cell. 2001; 104(1):71-81. DOI: 10.1016/s0092-8674(01)00192-1. View

11.

Stow J, Low P, Offenhauser C, Sangermani D . Cytokine secretion in macrophages and other cells: pathways and mediators. Immunobiology. 2009; 214(7):601-12. DOI: 10.1016/j.imbio.2008.11.005. View

12.

Tellam J, McIntosh S, James D . Molecular identification of two novel Munc-18 isoforms expressed in non-neuronal tissues. J Biol Chem. 1995; 270(11):5857-63. DOI: 10.1074/jbc.270.11.5857. View

13.

Hosono R, Hekimi S, Kamiya Y, Sassa T, Murakami S, Nishiwaki K . The unc-18 gene encodes a novel protein affecting the kinetics of acetylcholine metabolism in the nematode Caenorhabditis elegans. J Neurochem. 1992; 58(4):1517-25. DOI: 10.1111/j.1471-4159.1992.tb11373.x. View

14.

Neeft M, Wieffer M, de Jong A, Negroiu G, Metz C, van Loon A . Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cells. Mol Biol Cell. 2004; 16(2):731-41. PMC: 545907. DOI: 10.1091/mbc.e04-10-0923. View

15.

Gordon J, Galli S . Release of both preformed and newly synthesized tumor necrosis factor alpha (TNF-alpha)/cachectin by mouse mast cells stimulated via the Fc epsilon RI. A mechanism for the sustained action of mast cell-derived TNF-alpha during IgE-dependent.... J Exp Med. 1991; 174(1):103-7. PMC: 2118884. DOI: 10.1084/jem.174.1.103. View

16.

Tadokoro S, Kurimoto T, Nakanishi M, Hirashima N . Munc18-2 regulates exocytotic membrane fusion positively interacting with syntaxin-3 in RBL-2H3 cells. Mol Immunol. 2007; 44(13):3427-33. DOI: 10.1016/j.molimm.2007.02.013. View

17.

Haberman Y, Grimberg E, Fukuda M, Sagi-Eisenberg R . Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules. J Cell Sci. 2003; 116(Pt 21):4307-18. DOI: 10.1242/jcs.00719. View

18.

Koch H, Hofmann K, Brose N . Definition of Munc13-homology-domains and characterization of a novel ubiquitously expressed Munc13 isoform. Biochem J. 2000; 349(Pt 1):247-53. PMC: 1221144. DOI: 10.1042/0264-6021:3490247. View

19.

Pushparaj P, Tay H, Wang C, Hong W, Melendez A . VAMP8 is essential in anaphylatoxin-induced degranulation, TNF-alpha secretion, peritonitis, and systemic inflammation. J Immunol. 2009; 183(2):1413-8. DOI: 10.4049/jimmunol.0804061. View

20.

Haberman Y, Ziv I, Gorzalczany Y, Fukuda M, Sagi-Eisenberg R . Classical protein kinase C(s) regulates targeting of synaptotagmin IX to the endocytic recycling compartment. J Cell Sci. 2005; 118(Pt 8):1641-9. DOI: 10.1242/jcs.02276. View