Developmental Biology: a Growing Role for Computer Simulations
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Keeping cells separated in well-defined domains is essential for development. A new computational-experimental study elucidates the physical mechanisms that establish and maintain the dorsal-ventral compartment boundary in the Drosophila wing disc and demonstrates the increasing value of computer simulations in developmental biology.
Force-based three-dimensional model predicts mechanical drivers of cell sorting.
Revell C, Blumenfeld R, Chalut K Proc Biol Sci. 2019; 286(1895):20182495.
PMID: 30963946 PMC: 6364585. DOI: 10.1098/rspb.2018.2495.
Capabilities and Limitations of Tissue Size Control through Passive Mechanical Forces.
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