TRAIL As Biomarker and Potential Therapeutic Tool for Cardiovascular Diseases

Overview

Journal Curr Drug Targets

Publisher Bentham Science Publishers

Specialty Pharmacology

Date 2012 Jun 9

PMID 22676911

Citations 8

Authors

Stella Bernardi

Daniela Milani

Bruno Fabris

Paola Secchiero

Giorgio Zauli

Affiliations

Soon will be listed here.

Abstract

This review focuses on TNF-related apoptosis-inducing ligand (TRAIL), also called Apo2 ligand, a protein belonging to the TNF superfamily. TRAIL can be found either in its transmembrane or circulating form, and its mostly studied peripheral effect is the induction of cellular apoptosis. Here, we discuss the evidences supporting the use of TRAIL as biomarker of cardiovascular diseases as well as the evidences showing the potential beneficial therapeutic effects of TRAIL on cardiovascular diseases and diabetes.

Citing Articles

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Novel Biomarkers Differentiating Viral from Bacterial Infection in Febrile Children: Future Perspectives for Management in Clinical Praxis.

Rhedin S, Elfving K, Berggren A Children (Basel). 2021; 8(11).

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Remuzgo-Martinez S, Genre F, Lopez-Mejias R, Ubilla B, Mijares V, Pina T Sci Rep. 2016; 6:29713.

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Microgravity Induction of TRAIL Expression in Preosteoclast Cells Enhances Osteoclast Differentiation.

Sambandam Y, Baird K, Stroebel M, Kowal E, Balasubramanian S, Reddy S Sci Rep. 2016; 6:25143.

PMID: 27142480 PMC: 4855152. DOI: 10.1038/srep25143.

Soluble TRAIL Concentration in Serum Is Elevated in People with Hypercholesterolemia.

Cheng W, Liu F, Wang Z, Zhang Y, Zhao Y, Zhang Q PLoS One. 2015; 10(12):e0144015.

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