Microsatellite Instability is Associated with a Better Prognosis for Gastric Cancer Patients After Curative Surgery

Overview

Journal World J Surg

Publisher Wiley

Specialty General Surgery

Date 2012 Jun 7

PMID 22669398

Citations 49

Authors

Wen-Liang Fang

Shih-Ching Chang

Yuan-Tzu Lan

Kuo-Hung Huang

Jen-Hao Chen

Su-Shun Lo

Mao-Chih Hsieh

Anna Fen-Yau Li

Chew-Wun Wu

Shih-Hwa Chiou

Affiliations

Soon will be listed here.

Abstract

Background: Microsatellite instability (MSI) is one of the leading mechanisms for the carcinogenesis of gastric cancer. Its prognostic value is controversial.

Methods: Between May 1988 and Oct 2003, a total of 214 gastric cancer patients undergoing curative surgery were enrolled, and their MSI statuses were classified as MSI-H (high) or MSI-L/S (low/stable). The clinicopathologic characteristics of MSI-H and MSI-L/S gastric cancers were compared.

Results: The MSI-H tumors accounted for 11.7 % (n = 25) of the 214 total gastric cancers. Although not statistically significant, the MSI-H gastric cancers were more frequently located in the lower third of the stomach (64 % vs. 49.2 %) and were more often the intestinal type (72 % vs. 61.4 %) compared to the MSI-L/S gastric cancers. The MSI-H gastric cancers had a significantly better 5-year overall survival (OS) rate (68 % vs. 47.6 %, p = 0.030) and a trend of a better 3-year disease-free survival rate (71.8 % vs. 55.2 %, p = 0.076) compared to the MSI-L/S gastric cancers. A multivariate analysis revealed that pathologic TNM stage and MSI status were the independent prognostic factors for OS after curative surgery.

Conclusions: Compared to MSI-L/S tumors, MSI-H tumors are associated with a better OS rate for gastric cancer patients after R0 resection.

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