Immunology: Actin' Dangerously

Overview

Journal Nature

Specialty Science

Date 2012 Jun 5

PMID 22660316

Citations 5

Authors

Gordon D Brown

Affiliations

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Citing Articles

Exploring Clec9a in dendritic cell-based tumor immunotherapy for molecular insights and therapeutic potentials.

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Pleiotropic regulatory locus 1 maintains actin cytoskeleton integrity and cellular homeostasis to enable Arabidopsis root growth.

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Serological biomarkers for management of primary sclerosing cholangitis.

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RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells.

Tullett K, Tan P, Park H, Schittenhelm R, Michael N, Li R Elife. 2020; 9.

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The Role of Danger Associated Molecular Patterns in Human Fetal Membrane Weakening.

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References

Sancho D, Mourao-Sa D, Joffre O, Schulz O, Rogers N, Pennington D . Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin. J Clin Invest. 2008; 118(6):2098-110. PMC: 2391066. DOI: 10.1172/JCI34584. View

Huysamen C, Willment J, Dennehy K, Brown G . CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes. J Biol Chem. 2008; 283(24):16693-701. PMC: 2562446. DOI: 10.1074/jbc.M709923200. View

Iborra S, Izquierdo H, Martinez-Lopez M, Blanco-Menendez N, Reis e Sousa C, Sancho D . The DC receptor DNGR-1 mediates cross-priming of CTLs during vaccinia virus infection in mice. J Clin Invest. 2012; 122(5):1628-43. PMC: 3336985. DOI: 10.1172/JCI60660. View

Osorio F, Reis e Sousa C . Myeloid C-type lectin receptors in pathogen recognition and host defense. Immunity. 2011; 34(5):651-64. DOI: 10.1016/j.immuni.2011.05.001. View

Ahrens S, Zelenay S, Sancho D, Hanc P, Kjaer S, Feest C . F-actin is an evolutionarily conserved damage-associated molecular pattern recognized by DNGR-1, a receptor for dead cells. Immunity. 2012; 36(4):635-45. DOI: 10.1016/j.immuni.2012.03.008. View

Rock K, Lai J, Kono H . Innate and adaptive immune responses to cell death. Immunol Rev. 2011; 243(1):191-205. PMC: 3170128. DOI: 10.1111/j.1600-065X.2011.01040.x. View

Sancho D, Joffre O, Keller A, Rogers N, Martinez D, Hernanz-Falcon P . Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature. 2009; 458(7240):899-903. PMC: 2671489. DOI: 10.1038/nature07750. View

Caminschi I, Proietto A, Ahmet F, Kitsoulis S, Shin Teh J, Lo J . The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement. Blood. 2008; 112(8):3264-73. PMC: 2569177. DOI: 10.1182/blood-2008-05-155176. View

Zhang J, Czabotar P, Policheni A, Caminschi I, Wan S, Kitsoulis S . The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments. Immunity. 2012; 36(4):646-57. DOI: 10.1016/j.immuni.2012.03.009. View

10.

Zelenay S, Keller A, Whitney P, Schraml B, Deddouche S, Rogers N . The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice. J Clin Invest. 2012; 122(5):1615-27. PMC: 3336984. DOI: 10.1172/JCI60644. View

11.

Seong S, Matzinger P . Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses. Nat Rev Immunol. 2004; 4(6):469-78. DOI: 10.1038/nri1372. View