Diagnosis and Management of Gallbladder Polyps

Overview

Journal N Am J Med Sci

Specialty General Medicine

Date 2012 Jun 2

PMID 22655278

Citations 47

Authors

Ake Andren-Sandberg

Affiliations

Soon will be listed here.

Abstract

Gallbladder cancer is a rather uncommon disease, when it gives symptoms it has usually reached an incurable stage. Therefore, every attempt must be made to find the asymptomatic stages and look for premalignant gallbladder polyps. Even if gallbladder cancer is a rare disease, gallbladder polyps are common, only a few polyps develop to cancer. This makes gallbladder polyps another problem: which are the polyps that must be surgically removed, which shall be followed-up, or for how long? The author used the keyword "gallbladder polypsn" in PubMed and reviewed the scientific literatures published from January 2000 to December 2011. The present review article has summarized almost all respects of gallbladder polyp, including the risk factors, clinical diagnosis and management, and comments made from the author, in which clinical treatments are recommended. It is author's purpose that the 11-year-knowledge about gallbladder polyps summarized from all worlds' literatures is enough to know how clinicians will handle the next patient with gallbladder polyp.

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References

Azuma T, Yoshikawa T, Araida T, Takasaki K . Differential diagnosis of polypoid lesions of the gallbladder by endoscopic ultrasonography. Am J Surg. 2001; 181(1):65-70. DOI: 10.1016/s0002-9610(00)00526-2. View

Kianmanesh R, Scaringi S, Castel B, Flamant Y, Msika S . [Precancerous lesions of the gallbladder]. J Chir (Paris). 2007; 144(4):278-86. DOI: 10.1016/s0021-7697(07)91953-5. View

Sugiyama M, Atomi Y, Yamato T . Endoscopic ultrasonography for differential diagnosis of polypoid gall bladder lesions: analysis in surgical and follow up series. Gut. 2000; 46(2):250-4. PMC: 1727801. DOI: 10.1136/gut.46.2.250. View

Paslawski M, Krupski W, Zlomaniec J . The value of ultrasound harmonic imaging in the diagnostics of gall bladder cholesterol polyps. Ann Univ Mariae Curie Sklodowska Med. 2005; 59(2):293-7. View

Canturk Z, Senturk O, Canturk N, Anik Y . Prevalence and risk factors for gall bladder polyps. East Afr Med J. 2007; 84(7):336-41. View

Cho J, Park J, Kim Y, Kim H, Kim H, Hong S . Hypoechoic foci on EUS are simple and strong predictive factors for neoplastic gallbladder polyps. Gastrointest Endosc. 2009; 69(7):1244-50. DOI: 10.1016/j.gie.2008.10.017. View

Lee J, Lee K, Jung J, Ok S, Choi S, Lee K . [Factors associated with malignancy in gallbladder polyps without gallbladder stone]. Korean J Gastroenterol. 2008; 52(2):97-105. View

Park K, Kim S, Choi S, Lee W . Differentiation of nonneoplastic and neoplastic gallbladder polyps 1 cm or bigger with multi-detector row computed tomography. J Comput Assist Tomogr. 2010; 34(1):135-9. DOI: 10.1097/RCT.0b013e3181b382d7. View

Ito H, Hann L, DAngelica M, Allen P, Fong Y, DeMatteo R . Polypoid lesions of the gallbladder: diagnosis and followup. J Am Coll Surg. 2009; 208(4):570-5. DOI: 10.1016/j.jamcollsurg.2009.01.011. View

10.

Gallahan W, Conway J . Diagnosis and management of gallbladder polyps. Gastroenterol Clin North Am. 2010; 39(2):359-67, x. DOI: 10.1016/j.gtc.2010.02.001. View

11.

Stenberg B, Elliott S . Diagnosis of gallbladder problems using three-dimensional ultrasound. Eur Radiol. 2009; 20(4):908-14. DOI: 10.1007/s00330-009-1614-0. View

12.

Kwon W, Jang J, Lee S, Hwang D, Kim S . Clinicopathologic features of polypoid lesions of the gallbladder and risk factors of gallbladder cancer. J Korean Med Sci. 2009; 24(3):481-7. PMC: 2698196. DOI: 10.3346/jkms.2009.24.3.481. View

13.

Matos A, Baptista H, Pinheiro C, Martinho F . [Gallbladder polyps: how should they be treated and when?]. Rev Assoc Med Bras (1992). 2010; 56(3):318-21. DOI: 10.1590/s0104-42302010000300017. View

14.

Buckles D, Lindor K, LaRusso N, Petrovic L, Gores G . In primary sclerosing cholangitis, gallbladder polyps are frequently malignant. Am J Gastroenterol. 2002; 97(5):1138-42. DOI: 10.1111/j.1572-0241.2002.05677.x. View

15.

Kratzer W, Haenle M, Voegtle A, Mason R, Akinli A, Hirschbuehl K . Ultrasonographically detected gallbladder polyps: a reason for concern? A seven-year follow-up study. BMC Gastroenterol. 2008; 8:41. PMC: 2553794. DOI: 10.1186/1471-230X-8-41. View

16.

Park J, Hong S, Kim Y, Kim H, Kim H, Cho J . Long-term follow up of gallbladder polyps. J Gastroenterol Hepatol. 2008; 24(2):219-22. DOI: 10.1111/j.1440-1746.2008.05689.x. View

17.

Inui K, Yoshino J, Miyoshi H . Diagnosis of gallbladder tumors. Intern Med. 2011; 50(11):1133-6. DOI: 10.2169/internalmedicine.50.5255. View

18.

Bang S . [Natural course and treatment strategy of gallbladder polyp]. Korean J Gastroenterol. 2009; 53(6):336-40. DOI: 10.4166/kjg.2009.53.6.336. View

19.

Numata K, Oka H, Morimoto M, Sugimori K, Kunisaki R, Nihonmatsu H . Differential diagnosis of gallbladder diseases with contrast-enhanced harmonic gray scale ultrasonography. J Ultrasound Med. 2007; 26(6):763-74. DOI: 10.7863/jum.2007.26.6.763. View

20.

Choi W, Lee S, Kim M, Seo D, Kim H, Kim D . A new strategy to predict the neoplastic polyps of the gallbladder based on a scoring system using EUS. Gastrointest Endosc. 2000; 52(3):372-9. DOI: 10.1067/mge.2000.108041. View