Escort Aptamers: New Tools for the Targeted Delivery of Therapeutics into Cells

Overview

Journal Acta Naturae

Specialty Biology

Date 2012 Jun 1

PMID 22649701

Citations 6

Authors

A S Davydova

M A Vorobjeva

A G Venyaminova

Affiliations

Soon will be listed here.

Abstract

Escort aptamers are DNA or RNA sequences with high affinity to certain cell-surface proteins, which can be used for targeted delivery of various agents into cells of a definite type. The peculiarities of the selection of escort aptamers are discussed in this review. The methods used in selection of escort aptamers via the SELEX technique are considered, including selection against isolated cell-surface proteins, cell fragments, living eukaryotic cells, and bacteria. Particular attention is given to the design and chemical modification of escort aptamers. The different fields of application of escort aptamers are described, including the targeted delivery of siRNAs, nanoparticles, toxins, and photoagents, as well as the identification of specific cell markers and the detection or isolation of cells of a definite type. The potential for the application of escort aptamers in the development of new therapeutic agents and diagnostic systems is also discussed.

Citing Articles

Aptamers in Non-Small Cell Lung Cancer Treatment.

Wieleba I, Wojas-Krawczyk K, Krawczyk P Molecules. 2020; 25(14).

PMID: 32659994 PMC: 7396979. DOI: 10.3390/molecules25143138.

Diagnostic and Therapeutic Value of Aptamers in Envenomation Cases.

Ascoet S, De Waard M Int J Mol Sci. 2020; 21(10).

PMID: 32443562 PMC: 7278915. DOI: 10.3390/ijms21103565.

Selective eradication of human non-small cell lung cancer cells using aptamer-decorated nanoparticles harboring a cytotoxic drug cargo.

Engelberg S, Netzer E, Assaraf Y, Livney Y Cell Death Dis. 2019; 10(10):702.

PMID: 31541073 PMC: 6754387. DOI: 10.1038/s41419-019-1870-0.

Therapeutic aptamers: developmental potential as anticancer drugs.

Lee J, Kim H, Heo K BMB Rep. 2015; 48(4):234-7.

PMID: 25560701 PMC: 4436860. DOI: 10.5483/bmbrep.2015.48.4.277.

Aptamers: problems, solutions and prospects.

Lakhin A, Tarantul V, Gening L Acta Naturae. 2014; 5(4):34-43.

PMID: 24455181 PMC: 3890987.

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