Cyclin D1 Expression and Its Correlation with Histopathological Differentiation in Oral Squamous Cell Carcinoma

Overview

Journal ScientificWorldJournal

Publisher Wiley

Specialty Biology

Date 2012 May 26

PMID 22629227

Citations 19

Authors

Swati Saawarn

Madhusudan Astekar

Nisheeth Saawarn

Nidhi Dhakar

Shitalkumar Gomateshwar Sagari

Affiliations

Soon will be listed here.

Abstract

Background: Cyclin D1 regulates the G1 to S transition of cell cycle. Its deregulation or overexpression may lead to disturbance in the normal cell cycle control and tumour formation. Overexpression of cyclin D1 has been reported in various tumors of diverse histogenesis. This case control retrospective study was carried out to study the immunohistochemical reactivity and expression of cyclin D1 and its association with site, clinical staging, and histopathological differentiation of oral squamous cell carcinoma (OSCC).

Methods: Forty formalin-fixed paraffin-embedded tissue blocks of biopsy specimens of oral squamous cell carcinoma were immunohistochemically evaluated for expression of cyclin D1.

Results: Cyclin D1 expression was seen in 45% cases of OSCC. It did not correlate with site and clinical staging. Highest expression was seen in well-differentiated, followed by moderately differentiated, and poorly differentiated squamous cell carcinomas, with a statistically significant correlation.

Conclusion: Cyclin D1 expression significantly increases with increase in differentiation.

Citing Articles

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