The Impact of Infection and Tissue Damage in Solid-organ Transplantation

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2012 May 26

PMID 22627862

Citations 65

Authors

Anita S Chong

Maria-Luisa Alegre

Affiliations

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Abstract

Investigations over the past two decades are revealing complexities in the regulation of the innate immune response, and how this response, in turn, controls adaptive immunity. Microbial exposure, infections and tissue damage that accompany solid-organ transplantation result in the release of pathogen- and damage-associated molecular patterns, as well as pathogen- or allograft-derived antigens. Here, we review these triggers of innate and adaptive immunity, and discuss emerging paradigms of the many ways in which infections and tissue damage might directly or indirectly affect alloreactivity and the outcome of transplanted allografts.

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