The Bad, the Good, and the Ugly About Oxidative Stress

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2012 May 24

PMID 22619696

Citations 32

Authors

Marlene Jimenez-Del-Rio

Carlos Velez-Pardo

Affiliations

Soon will be listed here.

Abstract

Alzheimer's disease (AD), Parkinson's disease (PD), and cancer (e.g., leukemia) are the most devastating disorders affecting millions of people worldwide. Except for some kind of cancers, no effective and/or definitive therapeutic treatment aimed to reduce or to retard the clinic and pathologic symptoms induced by AD and PD is presently available. Therefore, it is urgently needed to understand the molecular basis of these disorders. Since oxidative stress (OS) is an important etiologic factor of the pathologic process of AD, PD, and cancer, understanding how intracellular signaling pathways respond to OS will have a significant implication in the therapy of these diseases. Here, we propose a model of minimal completeness of cell death signaling induced by OS as a mechanistic explanation of neuronal and cancer cell demise. This mechanism might provide the basis for therapeutic design strategies. Finally, we will attempt to associate PD, cancer, and OS. This paper critically analyzes the evidence that support the "oxidative stress model" in neurodegeneration and cancer.

Citing Articles

Effect of L. extract on growth performance, antioxidant capacity, and immune function in lambs.

Ma X, Niu Y, Nan S, Zhang W Front Vet Sci. 2024; 11:1367843.

PMID: 38659454 PMC: 11039921. DOI: 10.3389/fvets.2024.1367843.

Limited expression of Nrf2 in neurons across the central nervous system.

Levings D, Pathak S, Yang Y, Slattery M Redox Biol. 2023; 65:102830.

PMID: 37544245 PMC: 10428127. DOI: 10.1016/j.redox.2023.102830.

Limited Expression of in Neurons Across the Central Nervous System.

Levings D, Pathak S, Yang Y, Slattery M bioRxiv. 2023; .

PMID: 37214946 PMC: 10197674. DOI: 10.1101/2023.05.09.540014.

An antioxidant response element regulates the HIF1α axis in breast cancer cells.

Lacher S, Skon-Hegg C, Ruis B, Krznarich J, Slattery M Free Radic Biol Med. 2023; 204:243-251.

PMID: 37179033 PMC: 10321210. DOI: 10.1016/j.freeradbiomed.2023.05.003.

Shifting gears: Study of immune system parameters of male habitual marathon runners.

Panagoulias I, Charokopos N, Thomas I, Spantidea P, de Lastic A, Rodi M Front Immunol. 2023; 13:1009065.

PMID: 36713459 PMC: 9880332. DOI: 10.3389/fimmu.2022.1009065.

References

Brewer G . Why vitamin E therapy fails for treatment of Alzheimer's disease. J Alzheimers Dis. 2010; 19(1):27-30. PMC: 3023173. DOI: 10.3233/JAD-2010-1238. View

Vinish M, Anand A, Prabhakar S . Altered oxidative stress levels in Indian Parkinson's disease patients with PARK2 mutations. Acta Biochim Pol. 2011; 58(2):165-9. View

Ichijo H, Nishida E, Irie K, Ten Dijke P, Saitoh M, Moriguchi T . Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science. 1997; 275(5296):90-4. DOI: 10.1126/science.275.5296.90. View

McCord J, Fridovich I . Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem. 1969; 244(22):6049-55. View

Martin H, Teismann P . Glutathione--a review on its role and significance in Parkinson's disease. FASEB J. 2009; 23(10):3263-72. DOI: 10.1096/fj.08-125443. View

Sang T, Chang H, Lawless G, Ratnaparkhi A, Mee L, Ackerson L . A Drosophila model of mutant human parkin-induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine. J Neurosci. 2007; 27(5):981-92. PMC: 6673194. DOI: 10.1523/JNEUROSCI.4810-06.2007. View

Leto T, Geiszt M . Role of Nox family NADPH oxidases in host defense. Antioxid Redox Signal. 2006; 8(9-10):1549-61. DOI: 10.1089/ars.2006.8.1549. View

Kieburtz K, Ravina B . Why hasn't neuroprotection worked in Parkinson's disease?. Nat Clin Pract Neurol. 2007; 3(5):240-1. DOI: 10.1038/ncpneuro0491. View

Whitworth A . Drosophila models of Parkinson's disease. Adv Genet. 2011; 73:1-50. DOI: 10.1016/B978-0-12-380860-8.00001-X. View

10.

Payne S, Fogelgren B, Hess A, Seftor E, Wiley E, Fong S . Lysyl oxidase regulates breast cancer cell migration and adhesion through a hydrogen peroxide-mediated mechanism. Cancer Res. 2005; 65(24):11429-36. DOI: 10.1158/0008-5472.CAN-05-1274. View

11.

Polytarchou C, Hatziapostolou M, Papadimitriou E . Hydrogen peroxide stimulates proliferation and migration of human prostate cancer cells through activation of activator protein-1 and up-regulation of the heparin affin regulatory peptide gene. J Biol Chem. 2005; 280(49):40428-35. DOI: 10.1074/jbc.M505120200. View

12.

Yang D, Tournier C, Wysk M, Lu H, Xu J, Davis R . Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity. Proc Natl Acad Sci U S A. 1997; 94(7):3004-9. PMC: 20312. DOI: 10.1073/pnas.94.7.3004. View

13.

Mehan S, Meena H, Sharma D, Sankhla R . JNK: a stress-activated protein kinase therapeutic strategies and involvement in Alzheimer's and various neurodegenerative abnormalities. J Mol Neurosci. 2010; 43(3):376-90. DOI: 10.1007/s12031-010-9454-6. View

14.

Schapira A, Gegg M . Mitochondrial contribution to Parkinson's disease pathogenesis. Parkinsons Dis. 2011; 2011:159160. PMC: 3109314. DOI: 10.4061/2011/159160. View

15.

Maheshwari A, Misro M, Aggarwal A, Sharma R, Nandan D . N-acetyl-L-cysteine counteracts oxidative stress and prevents H2O2 induced germ cell apoptosis through down-regulation of caspase-9 and JNK/c-Jun. Mol Reprod Dev. 2011; 78(2):69-79. DOI: 10.1002/mrd.21268. View

16.

Visioli F, Alarcon de la Lastra C, Andres-Lacueva C, Aviram M, Calhau C, Cassano A . Polyphenols and human health: a prospectus. Crit Rev Food Sci Nutr. 2011; 51(6):524-46. DOI: 10.1080/10408391003698677. View

17.

Badrick A, Jones C . Reorganizing metals: the use of chelating compounds as potential therapies for metal-related neurodegenerative disease. Curr Top Med Chem. 2010; 11(5):543-52. DOI: 10.2174/156802611794785181. View

18.

Schaffer S, Halliwell B . Do polyphenols enter the brain and does it matter? Some theoretical and practical considerations. Genes Nutr. 2011; 7(2):99-109. PMC: 3316747. DOI: 10.1007/s12263-011-0255-5. View

19.

Reynolds A, Laurie C, Mosley R, Gendelman H . Oxidative stress and the pathogenesis of neurodegenerative disorders. Int Rev Neurobiol. 2007; 82:297-325. DOI: 10.1016/S0074-7742(07)82016-2. View

20.

Lee F, HAGLER J, Chen Z, Maniatis T . Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway. Cell. 1997; 88(2):213-22. DOI: 10.1016/s0092-8674(00)81842-5. View