Bisphosphonate Use and Increased Incidence of Subtrochanteric Fracture in South Korea: Results from the National Claim Registry

Overview

Journal Osteoporos Int

Specialties Endocrinology
Orthopedics

Date 2012 May 24

PMID 22618268

Citations 31

Authors

Y-K Lee

Y-C Ha

C Park

J J Yoo

C S Shin

K-H Koo

Affiliations

Soon will be listed here.

Abstract

Summary: We evaluated trends in the incidences of typical and atypical hip fracture in relation to bisphosphonate use in Korea from 2006 to 2010, using nationwide data obtained from the Health Insurance Review and Assessment Service (HIRA).

Introduction: Recently, atypical hip fractures in the subtrochanteric region have been reported among patients on bisphosphonate. However, the association between atypical hip fracture and bisphosphonate is controversial. We evaluated trends in the incidences of typical and atypical hip fracture in relation to bisphosphonate use in Korea from 2006 to 2010, using nationwide data obtained from the HIRA.

Methods: All new visits or admissions to clinics or hospitals for a typical and atypical hip fractures were recorded nationwide by HIRA using the ICD-10 code classification. Typical and atypical hip fractures were defined as femoral neck/intertrochanteric and subtrochanteric fracture, respectively. Bisphosphonate prescription data were also abstracted from the HIRA database.

Results: The absolute number of typical and atypical hip fracture increased during the study period. Although age-adjusted incidence rates of typical hip fractures were stable in men and women, those of atypical hip fractures increased in women. Nationally, the annual numbers of prescriptions of bisphosphonate also increased during the study period.

Conclusions: The results of this study suggest a possible causal relationship between bisphosphonate use and the increased incidence of atypical hip fracture in Korea.

Citing Articles

Sodium-Glucose Cotransporter 2 Inhibitors vs Incretin-Based Drugs and Risk of Fractures for Type 2 Diabetes.

Ko H, Bea S, Jeong H, Park S, Cho Y, Kong S JAMA Netw Open. 2023; 6(9):e2335797.

PMID: 37751205 PMC: 10523172. DOI: 10.1001/jamanetworkopen.2023.35797.

The Korean hip fracture registry study.

Park J, Ha Y, Kim J, Kim T, Kim J, Baek S BMC Musculoskelet Disord. 2023; 24(1):449.

PMID: 37268896 PMC: 10236602. DOI: 10.1186/s12891-023-06546-z.

Validation of Operational Definition to Identify Patients with Osteoporotic Hip Fractures in Administrative Claims Data.

Lee Y, Yoo J, Kim T, Ha Y, Koo K, Choi H Healthcare (Basel). 2022; 10(9).

PMID: 36141336 PMC: 9498336. DOI: 10.3390/healthcare10091724.

Operational Definition Identifying Osteoporotic Vertebral Fractures in the Claims Database.

Yu M, Hong N, Lee S, Kim H, Park H, Park S J Korean Med Sci. 2022; 37(32):e249.

PMID: 35971763 PMC: 9424695. DOI: 10.3346/jkms.2022.37.e249.

Current Incidence and Future Projection of Periprosthetic Fractures in South Korea: A Study Based on National Claim Database.

Park J, Won S, Kim H, Won S, Lee Y, Koo K Orthop Surg. 2022; 14(3):530-535.

PMID: 35098681 PMC: 8927022. DOI: 10.1111/os.13219.

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