Immunogenicity and Safety of Measles-mumps-rubella and Varicella Vaccines Coadministered with a Fourth Dose of Haemophilus Influenzae Type B and Neisseria Meningitidis Serogroups C and Y-tetanus Toxoid Conjugate Vaccine in Toddlers: a Pooled...

Overview

Journal Hum Vaccin Immunother

Specialty Allergy & Immunology

Date 2012 May 24

PMID 22617844

Citations 5

Authors

Kristina Bryant

Jodie McVernon

Colin Marchant

Terry Nolan

Gary Marshall

Peter Richmond

Helen Marshall

Michael Nissen

Stephen Lambert

Emmanuel Aris

Narcisa Mesaros

Jacqueline Miller

Affiliations

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Abstract

A pooled analysis was conducted of 1257 toddlers who received a fourth dose of Haemophilus influenzae type b-Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine (HibMenCY-TT) or Hib conjugate vaccine (Hib polysaccharide conjugated to N. meningitidis outer membrane protein) coadministered with measles-mumps-rubella (MMR) and varicella (VAR) vaccines (NCT00134719/NCT00289783). Noninferiority of immunological responses to MMR and VAR was demonstrated between groups and incidences of MMR- and VAR-specific solicited symptoms were similar, indicating that HibMenCY-TT can be coadministered with MMR and VAR.

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References

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