Efficient, Divergent Synthesis of Cryptophycin Unit A Analogues

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2012 May 24

PMID 22617820

Citations 5

Authors

Kyle L Bolduc

Scott D Larsen

David H Sherman

Affiliations

Soon will be listed here.

Abstract

A flexible and divergent synthesis of cryptophycin unit A analogues is described. This method relies on iridium-catalysed stereo- and enantioselective crotylation and chemoselective one-pot oxidative olefination to access common intermediate . Heck, cross metathesis, and Suzuki-Miyaura reactions are illustrated for the generation of methyl ester unit A analogues .

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