Reproducibility of Cerebral Blood Flow Assessment Using a Quantitative SPECT Reconstruction Program and Split-dose 123I-iodoamphetamine in Institutions with Different γ-cameras and Collimators

Overview

Journal J Cereb Blood Flow Metab

Publisher Sage Publications

Specialties Cardiology & Vascular Diseases
Endocrinology
Neurology

Date 2012 May 24

PMID 22617648

Citations 9

Authors

Hiroshi Yoneda

Satoshi Shirao

Hiroyasu Koizumi

Fumiaki Oka

Hideyuki Ishihara

Kunitsugu Ichiro

Tetsuhiro Kitahara

Hidehiro Iida

Michiyasu Suzuki

Affiliations

Soon will be listed here.

Abstract

Single photon emission computed tomography (SPECT) is used widely in clinical studies. However, the technique requires image reconstruction and the methods for correcting scattered radiation and absorption are not standardized among SPECT procedures. Therefore, quantitation of cerebral blood flow (CBF) may not be constant across SPECT models. The quantitative SPECT (QSPECT) software package has been developed for standardization of CBF. Using the QSPECT/dual-table autoradiographic (DTARG) method, CBF and cerebral vascular reactivity (CVR) at rest and after acetazolamide challenge can be evaluated using (123)I-iodoamphetamine in a single SPECT session. In this study, we examined the reproducibility of quantitative regional CBF and CVR in QSPECT/DTARG using different SPECT models at two facilities. The subjects were nine patients with chronic cerebral ischemic disease who underwent QSPECT/DTARG at both facilities with use of different γ-cameras and collimators. There were significant correlations for CBF at rest and after acetazolamide challenge measured at the two facilities. The consistency of the CBFs of the patients measured at the two facilities were good in all cases. Our results show that CBF measured by QSPECT/DTARG in the same patients is reproducible in different SPECT models. This indicates that standardized evaluation of CBF can be performed in large multicenter studies.

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References

Matsumoto S, Shimodozono M, Miyata R, Kawahira K . Effect of cilostazol administration on cerebral hemodynamics and rehabilitation outcomes in poststroke patients. Int J Neurosci. 2011; 121(5):271-8. DOI: 10.3109/00207454.2010.551431. View

Kim K, Watabe H, Hayashi T, Hayashida K, Katafuchi T, Enomoto N . Quantitative mapping of basal and vasareactive cerebral blood flow using split-dose 123I-iodoamphetamine and single photon emission computed tomography. Neuroimage. 2006; 33(4):1126-35. DOI: 10.1016/j.neuroimage.2006.06.064. View

Frackowiak R, Lenzi G, Jones T, Heather J . Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15O and positron emission tomography: theory, procedure, and normal values. J Comput Assist Tomogr. 1980; 4(6):727-36. DOI: 10.1097/00004728-198012000-00001. View

Hirano T, Minematsu K, Hasegawa Y, Tanaka Y, Hayashida K, Yamaguchi T . Acetazolamide reactivity on 123I-IMP single photon emission computed tomography in patients with major cerebral artery occlusive disease: correlation with positron emission tomography parameters. J Cereb Blood Flow Metab. 1994; 14(5):763-70. DOI: 10.1038/jcbfm.1994.97. View

Yamauchi H, Fukuyama H, Nagahama Y, Nabatame H, Ueno M, Nishizawa S . Significance of increased oxygen extraction fraction in five-year prognosis of major cerebral arterial occlusive diseases. J Nucl Med. 2000; 40(12):1992-8. View

Barnett H, Taylor D, Haynes R, Sackett D, Peerless S, Ferguson G . Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med. 1991; 325(7):445-53. DOI: 10.1056/NEJM199108153250701. View

Nakagawara J, Hyogo T, Kataoka T, Hayase K, Kasuya J, Kamiyama K . [Role of neuroimaging(SPECT/PET, CT/MRI) in thrombolytic therapy]. No To Shinkei. 2000; 52(10):873-82. View

Iida H, Akutsu T, Endo K, Fukuda H, Inoue T, Ito H . A multicenter validation of regional cerebral blood flow quantitation using [123I]iodoamphetamine and single photon emission computed tomography. J Cereb Blood Flow Metab. 1996; 16(5):781-93. DOI: 10.1097/00004647-199609000-00003. View

Minoshima S, Koeppe R, Frey K, Kuhl D . Anatomic standardization: linear scaling and nonlinear warping of functional brain images. J Nucl Med. 1994; 35(9):1528-37. View

10.

Sato T, Hanyu H, Hirao K, Kanetaka H, Sakurai H, Iwamoto T . Efficacy of PPAR-γ agonist pioglitazone in mild Alzheimer disease. Neurobiol Aging. 2009; 32(9):1626-33. DOI: 10.1016/j.neurobiolaging.2009.10.009. View

11.

Nakagawara J . [Clinical neuroimaging of cerebral ischemia]. No To Shinkei. 1999; 51(6):502-13. View

12.

Hatazawa J, Iida H, Shimosegawa E, Sato T, Murakami M, Miura Y . Regional cerebral blood flow measurement with iodine-123-IMP autoradiography: normal values, reproducibility and sensitivity to hypoperfusion. J Nucl Med. 1997; 38(7):1102-8. View

13.

Mizumura S, Nakagawara J, Takahashi M, Kumita S, Cho K, Nakajo H . Three-dimensional display in staging hemodynamic brain ischemia for JET study: objective evaluation using SEE analysis and 3D-SSP display. Ann Nucl Med. 2004; 18(1):13-21. DOI: 10.1007/BF02985609. View

14.

Bland J, Altman D . Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986; 1(8476):307-10. View

15.

Iida H, Nakagawara J, Hayashida K, Fukushima K, Watabe H, Koshino K . Multicenter evaluation of a standardized protocol for rest and acetazolamide cerebral blood flow assessment using a quantitative SPECT reconstruction program and split-dose 123I-iodoamphetamine. J Nucl Med. 2010; 51(10):1624-31. DOI: 10.2967/jnumed.110.078352. View

16.

Iida H, Itoh H, Nakazawa M, Hatazawa J, Nishimura H, Onishi Y . Quantitative mapping of regional cerebral blood flow using iodine-123-IMP and SPECT. J Nucl Med. 1994; 35(12):2019-30. View

17.

Iida H, Narita Y, Kado H, Kashikura A, Sugawara S, Shoji Y . Effects of scatter and attenuation correction on quantitative assessment of regional cerebral blood flow with SPECT. J Nucl Med. 1998; 39(1):181-9. View

18.

Kai Y, Watanabe M, Morioka M, Hirano T, Yano S, Ohmori Y . Cilostazol improves symptomatic intracranial artery stenosis - Evaluation of cerebral blood flow with single photon emission computed tomography. Surg Neurol Int. 2011; 2:8. PMC: 3031048. DOI: 10.4103/2152-7806.76145. View

19.

Yamauchi H, Kudoh T, Kishibe Y, Iwasaki J, Kagawa S . Selective neuronal damage and chronic hemodynamic cerebral ischemia. Ann Neurol. 2007; 61(5):454-65. DOI: 10.1002/ana.21104. View