Role of Dopamine Receptors in ADHD: a Systematic Meta-analysis

Overview

Journal Mol Neurobiol

Specialties Molecular Biology
Neurology

Date 2012 May 22

PMID 22610946

Citations 102

Authors

Jing Wu

Haifan Xiao

Hongjuan Sun

Li Zou

Ling-Qiang Zhu

Affiliations

Soon will be listed here.

Abstract

The dopaminergic system plays a pivotal role in the central nervous system via its five diverse receptors (D1-D5). Dysfunction of dopaminergic system is implicated in many neuropsychological diseases, including attention deficit hyperactivity disorder (ADHD), a common mental disorder that prevalent in childhood. Understanding the relationship of five different dopamine (DA) receptors with ADHD will help us to elucidate different roles of these receptors and to develop therapeutic approaches of ADHD. This review summarized the ongoing research of DA receptor genes in ADHD pathogenesis and gathered the past published data with meta-analysis and revealed the high risk of DRD5, DRD2, and DRD4 polymorphisms in ADHD.

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