Extracellular Matrix and Cytoskeletal Dynamics During Branching Morphogenesis

Overview

Journal Organogenesis

Specialties Anatomy & Histology
Biology
Biotechnology

Date 2012 May 22

PMID 22609561

Citations 35

Authors

Hye Young Kim

Celeste M Nelson

Affiliations

Soon will be listed here.

Abstract

Branching morphogenesis is a fundamental developmental process which results in amplification of epithelial surface area for exchanging molecules in organs including the lung, kidney, mammary gland and salivary gland. These complex tree-like structures are built by iterative rounds of simple routines of epithelial morphogenesis, including bud formation, extension, and bifurcation, that require constant remodeling of the extracellular matrix (ECM) and the cytoskeleton. In this review, we highlight the current understanding of the role of the ECM and cytoskeletal dynamics in branching morphogenesis across these different organs. The cellular and molecular mechanisms shared during this morphogenetic process provide insight into the development of other branching organs.

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