A Deficiency in Haem Oxygenase-1 Induces Foetal Growth Restriction by Placental Vasculature Defects

Overview

Journal Acta Paediatr

Specialty Pediatrics

Date 2012 May 19

PMID 22594519

Citations 17

Authors

Ronald J Wong

Hui Zhao

David K Stevenson

Affiliations

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Abstract

Unlabelled: Haem oxygenase-1 (HO-1), the rate-limiting enzyme in haem degradation, plays a role in angiogenesis and vasculogenesis and is highly expressed in the placenta. Deficiencies in HO-1 are associated with several pregnancy disorders, such as recurrent miscarriages and pre-eclampsia. The unique combination of tissue protective, smooth muscle relaxing and angiogenesis regulatory properties makes HO-1 a key player in the maintenance of a healthy pregnancy through a direct effect on placental structural and vascular development, thus affecting foetal development.

Conclusion: Therefore, we conclude that HO-1 plays an important role in placental vasculature development and a deficiency in HO-1 may contribute to pregnancy complications, such as pre-eclampsia, spontaneous abortions and premature births.

Citing Articles

Absence of Heme Oxygenase-1 Affects Trophoblastic Spheroid Implantation and Provokes Dysregulation of Stress and Angiogenesis Gene Expression in the Uterus.

Zenclussen M, Ulrich S, Bauer M, Fink B, Zenclussen A, Schumacher A Cells. 2024; 13(5.

PMID: 38474340 PMC: 10930528. DOI: 10.3390/cells13050376.

Bioinformatics Analysis Identifies Potential Related Genes in the Pathogenesis of Intrauterine Fetal Growth Retardation.

Xiao C, Wang Y, Fan Y Evol Bioinform Online. 2022; 18:11769343221112780.

PMID: 35923419 PMC: 9340335. DOI: 10.1177/11769343221112780.

The Impact of Hypoxia in Early Pregnancy on Placental Cells.

Zhao H, Wong R, Stevenson D Int J Mol Sci. 2021; 22(18).

PMID: 34575844 PMC: 8466283. DOI: 10.3390/ijms22189675.

Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring.

Ozen M, Zhao H, Kalish F, Yang Y, Jantzie L, Wong R PLoS One. 2021; 16(6):e0252642.

PMID: 34086785 PMC: 8177474. DOI: 10.1371/journal.pone.0252642.

The Role of Heme Oxygenase-1 Promoter Polymorphisms in Perinatal Disease.

Nakasone R, Ashina M, Abe S, Tanimura K, Rostenberghe H, Fujioka K Int J Environ Res Public Health. 2021; 18(7).

PMID: 33805292 PMC: 8037596. DOI: 10.3390/ijerph18073520.