Association of Promoter Region Single Nucleotide Polymorphisms at Positions -819C/T and -592C/A of Interleukin 10 Gene with Ischemic Heart Disease

Overview

Journal Inflamm Res

Specialties Allergy & Immunology
Pathology

Date 2012 May 18

PMID 22592860

Citations 8

Authors

Gyeong-Im Yu

Ho-Chan Cho

Yun-Kyeong Cho

Hyoung-Seob Park

Hyuck-Jun Yoon

Hyung-Seop Kim

Chang-Wook Nam

Yoon-Nyun Kim

Kwon-Bae Kim

Eunyoung Ha

Dong-Hoon Shin

Seung-Ho Hur

Affiliations

Soon will be listed here.

Abstract

Objective: Ischemic heart disease (IHD) is a disease characterized by ischemia of the heart muscle, usually due to coronary artery disease. Interleukin-10 (IL10) is a proinflammatory cytokine known to protect endothelial function. In this study, we investigated the association of promoter region polymorphisms of the IL10 gene with IHD.

Methods: We recruited 313 control and 173 IHD patients. The selected SNPs in IL10 were genotyped using pyrosequencing.

Results: SNPs at positions -592C/A and -819C/T were statistically associated with IHD (P = 0.014 and P = 0.037). Similarly, the mean value of C-reactive protein in the C allele at -592C/A and -819C/T was significantly higher than that in the A allele at -592C/A (P = 0.026) and T allele at -819C/T (P = 0.026). The presence of hypertension in the C allele at -592C/A and -819C/T was significantly more frequent than that in the A allele at -592C/A (P = 0.044) and T allele at -819C/T (P = 0.044). In the haplotype of two SNPs (-592C/A and -819C/T), one haplotype (CC) presented an association with IHD (P = 0.012).

Conclusions: These results indicate that the C allele with SNPs at position -592C/A and -819C/T of IL10 gene may be associated with IHD in the Korean population.

Citing Articles

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