Correlation of Expression of Hypoxia-related Proteins with Prognosis in Oral Squamous Cell Carcinoma Patients

Overview

Journal Oral Maxillofac Surg

Specialties Dentistry
General Surgery

Date 2012 May 18

PMID 22592457

Citations 31

Authors

A W Eckert

M Kappler

J Schubert

H Taubert

Affiliations

Soon will be listed here.

Abstract

Introduction: Hypoxia plays a major role in tumor progression, therapy resistance and for prognosis of oral squamous cell carcinoma (OSCC). The crucial step as a response to hypoxia is the activation and stabilization of the alpha subunit of hypoxia inducible factor 1 (HIF-1α). HIF-1: HIF-1 regulates the expression of different genes to adapt the tumor cells to reduced oxygenation. The HIF-1 system is intrinsic regulated by von Hippel-Lindau protein (pVHL). Main downstream proteins are the glucose transporter 1 (GLUT-1), carbonic anhydrase IX (CAIX), and vascular endothelial growth factor (VEGF). For therapeutical stratification in OSCC, it is important to understand the mechanism caused by hypoxic stress and to comprehend the resulting adaptive process in cancer cells. Therefore, an overview of HIF-1α-depending protein expression, focussed on the expression of GLUT-1, CAIX, and VEGF and their prognostic significance in OSCC is given.

Conclusion: Several unique roles of hypoxic pathway in the context of tumor progression are described in this review. As a consequence, a marker panel is proposed to allow a more individualized prognosis in OSCC patients. This marker panel should include beside HIF-1α, pVHL, and GLUT-1.

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References

Kyzas P, Cunha I, Ioannidis J . Prognostic significance of vascular endothelial growth factor immunohistochemical expression in head and neck squamous cell carcinoma: a meta-analysis. Clin Cancer Res. 2005; 11(4):1434-40. DOI: 10.1158/1078-0432.CCR-04-1870. View

Kim K, Li S, Cha J, Zhang X, Cha I . Significance of molecular markers in survival prediction of oral squamous cell carcinoma. Head Neck. 2011; 34(7):929-36. DOI: 10.1002/hed.21856. View

Eckert A, Lautner M, Schutze A, Bolte K, Bache M, Kappler M . Co-expression of Hif1alpha and CAIX is associated with poor prognosis in oral squamous cell carcinoma patients. J Oral Pathol Med. 2009; 39(4):313-7. DOI: 10.1111/j.1600-0714.2009.00829.x. View

Uehara M, Sano K, Ikeda H, Nonaka M, Asahina I . Hypoxia-inducible factor 1 alpha in oral squamous cell carcinoma and its relation to prognosis. Oral Oncol. 2008; 45(3):241-6. DOI: 10.1016/j.oraloncology.2008.05.007. View

Mayer A, Hockel M, Vaupel P . Endogenous hypoxia markers: case not proven!. Adv Exp Med Biol. 2008; 614:127-36. DOI: 10.1007/978-0-387-74911-2_15. View

Sedivy R, Beck-Mannagetta J, Haverkampf C, Battistutti W, Honigschnabl S . Expression of vascular endothelial growth factor-C correlates with the lymphatic microvessel density and the nodal status in oral squamous cell cancer. J Oral Pathol Med. 2003; 32(8):455-60. DOI: 10.1034/j.1600-0714.2003.00168.x. View

Semenza G . Targeting HIF-1 for cancer therapy. Nat Rev Cancer. 2003; 3(10):721-32. DOI: 10.1038/nrc1187. View

Rojas Ayala F, Rocha R, Carvalho K, Carvalho A, da Cunha I, Lourenco S . GLUT1 and GLUT3 as potential prognostic markers for Oral Squamous Cell Carcinoma. Molecules. 2010; 15(4):2374-87. PMC: 6257354. DOI: 10.3390/molecules15042374. View

Vaupel P, Mayer A . Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev. 2007; 26(2):225-39. DOI: 10.1007/s10555-007-9055-1. View

10.

Smith B, Smith G, Carter D, DiGiovanna M, Kasowitz K, Sasaki C . Molecular marker expression in oral and oropharyngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2001; 127(7):780-5. View

11.

Reisser C, Eichhorn K, Herold-Mende C . [Glucose uptake in malignant tumors of the head and neck]. HNO. 1999; 47(8):712-7. DOI: 10.1007/s001060050450. View

12.

Tian M, Zhang H, Nakasone Y, Mogi K, Endo K . Expression of Glut-1 and Glut-3 in untreated oral squamous cell carcinoma compared with FDG accumulation in a PET study. Eur J Nucl Med Mol Imaging. 2003; 31(1):5-12. DOI: 10.1007/s00259-003-1316-9. View

13.

De Cicco R, Watson J, Bassi D, Litwin S, Klein-Szanto A . Simultaneous expression of furin and vascular endothelial growth factor in human oral tongue squamous cell carcinoma progression. Clin Cancer Res. 2004; 10(13):4480-8. DOI: 10.1158/1078-0432.CCR-03-0670. View

14.

Mohamed K, Le A, Duong H, Wu Y, Zhang Q, Messadi D . Correlation between VEGF and HIF-1alpha expression in human oral squamous cell carcinoma. Exp Mol Pathol. 2004; 76(2):143-52. DOI: 10.1016/j.yexmp.2003.10.005. View

15.

Potente M, Gerhardt H, Carmeliet P . Basic and therapeutic aspects of angiogenesis. Cell. 2011; 146(6):873-87. DOI: 10.1016/j.cell.2011.08.039. View

16.

Mayer A, Hockel M, Horn L, Schmidberger H, Vaupel P . GLUT-1 staining of squamous cell carcinomas of the uterine cervix identifies a novel element of invasion. Int J Oncol. 2010; 38(1):145-50. View

17.

Schliephake H . Prognostic relevance of molecular markers of oral cancer--a review. Int J Oral Maxillofac Surg. 2003; 32(3):233-45. DOI: 10.1054/ijom.2002.0383. View

18.

Eckert A, Lautner M, Schutze A, Taubert H, Schubert J, Bilkenroth U . Coexpression of hypoxia-inducible factor-1α and glucose transporter-1 is associated with poor prognosis in oral squamous cell carcinoma patients. Histopathology. 2011; 58(7):1136-47. DOI: 10.1111/j.1365-2559.2011.03806.x. View

19.

Perez-Sayans M, Suarez-Penaranda J, Pilar G, Barros-Angueira F, Gandara-Rey J, Garcia-Garcia A . Hypoxia-inducible factors in OSCC. Cancer Lett. 2011; 313(1):1-8. DOI: 10.1016/j.canlet.2011.08.017. View

20.

Shemirani B, Crowe D . Hypoxic induction of HIF-1alpha and VEGF expression in head and neck squamous cell carcinoma lines is mediated by stress activated protein kinases. Oral Oncol. 2002; 38(3):251-7. DOI: 10.1016/s1368-8375(01)00052-5. View