PTK7 As a Novel Marker for Favorable Gastric Cancer Patient Survival

Overview

Journal J Surg Oncol

Specialties General Surgery
Oncology

Date 2012 May 16

PMID 22585737

Citations 31

Authors

Yi Lin

Lian-Hai Zhang

Xiao-Hong Wang

Xiao-Fang Xing

Xiao-Jing Cheng

Bin Dong

Ying Hu

Hong Du

Ying-ai Li

Yu-Bing Zhu

Ning Ding

Yun-Xia Du

Ji-You Li

Jia-Fu Ji

Affiliations

Soon will be listed here.

Abstract

Background And Objectives: Protein tyrosine kinase 7 (PTK7) plays important functions in several cancer types but its expression in gastric cancer remains unknown. This study was designed to investigate PTK7 expression in gastric cancer.

Methods: PTK7 expression was assessed by immunohistochemistry in 201 gastric cancer patients. The relationship between PTK7 expression and clinicopathological features and patients prognosis were statistically analyzed.

Results: PTK7 expression was detected in 56.72% (114 of 201) of gastric cancer patients. The immunostaining was predominantly localized in the cytoplasm. The statistical analyses showed that PTK7 expression was more frequently detected in patients with well-differentiated tumors (P = 0.001). Furthermore, PTK7 expression was significantly related to the favorable overall survival (OS; P = 0.012) and disease-free survival (DFS; P = 0.009). Multivariate Cox regression analyses revealed that PTK7 expression was an independent prognostic factor for both favorable OS (P = 0.028) and DFS (P = 0.012).

Conclusion: Our findings demonstrate that PTK7 can serve as a novel prognostic biomarker for gastric cancer patients.

Citing Articles

PTK7: an underestimated contributor to human cancer.

Jin Z, Guo T, Zhang X, Wang X, Liu Y Front Oncol. 2024; 14:1448695.

PMID: 39474113 PMC: 11518688. DOI: 10.3389/fonc.2024.1448695.

Structure-based investigation of a DNA aptamer targeting PTK7 reveals an intricate 3D fold guiding functional optimization.

He A, Wan L, Zhang Y, Yan Z, Guo P, Han D Proc Natl Acad Sci U S A. 2024; 121(29):e2404060121.

PMID: 38985770 PMC: 11260122. DOI: 10.1073/pnas.2404060121.

Recent insights into the therapeutic strategies targeting the pseudokinase PTK7 in cancer.

Dessaux C, Ganier L, Guiraud L, Borg J Oncogene. 2024; 43(26):1973-1984.

PMID: 38773263 PMC: 11196218. DOI: 10.1038/s41388-024-03060-x.

Enzymatic Synthesis of Aptamer-Polynucleotide Nanoparticles with High Anticancer Drug Loading for Targeted Delivery.

Deshpande S, Yang Y, Zauscher S, Chilkoti A Biomacromolecules. 2023; 25(1):155-164.

PMID: 38051194 PMC: 11495896. DOI: 10.1021/acs.biomac.3c00888.

Cell Surface Labeling and Detection of Protein Tyrosine Kinase 7 via Covalent Aptamers.

Albright S, Cacace M, Tivon Y, Deiters A J Am Chem Soc. 2023; 145(30):16458-16463.

PMID: 37473438 PMC: 10401710. DOI: 10.1021/jacs.3c02752.