Post-surgical Follow-up of Primary Hyperparathyroidism Associated with Multiple Endocrine Neoplasia Type 1

Overview

Journal Clinics (Sao Paulo)

Publisher Elsevier

Specialty General Medicine

Date 2012 May 16

PMID 22584724

Citations 9

Authors

Flavia L Coutinho

Delmar M Lourenco Jr

Rodrigo A Toledo

Fabio L M Montenegro

Sergio P A Toledo

Affiliations

Soon will be listed here.

Abstract

The bone mineral density increments in patients with sporadic primary hyperparathyroidism after parathyroidectomy have been studied by several investigators, but few have investigated this topic in primary hyperparathyroidism associated with multiple endocrine neoplasia type 1. Further, as far as we know, only two studies have consistently evaluated bone mineral density values after parathyroidectomy in cases of primary hyperparathyroidism associated with multiple endocrine neoplasia type 1. Here we revised the impact of parathyroidectomy (particularly total parathyroidectomy followed by autologous parathyroid implant into the forearm) on bone mineral density values in patients with primary hyperparathyroidism associated with multiple endocrine neoplasia type 1. Significant increases in bone mineral density in the lumbar spine and femoral neck values were found, although no short-term (15 months) improvement in bone mineral density at the proximal third of the distal radius was observed. Additionally, short-term and medium-term calcium and parathyroid hormone values after parathyroidectomy in patients with primary hyperparathyroidism associated with multiple endocrine neoplasia type 1 are discussed. In most cases, this surgical approach was able to restore normal calcium/parathyroid hormone levels and ultimately lead to discontinuation of calcium and calcitriol supplementation.

Citing Articles

Bone mineral density over ten years after primary parathyroidectomy in multiple endocrine neoplasia type 1.

Kuusela E, Kostiainen I, Ritvonen E, Ryhanen E, Schalin-Jantti C JBMR Plus. 2024; 8(12):ziae129.

PMID: 39575107 PMC: 11579653. DOI: 10.1093/jbmrpl/ziae129.

[Severe bone complications of primary hyperparathyroidism in a young patient with the rare verified mutation of ].

Eremkina A, Sazonova D, Bibik E, Sheikhova A, Khairieva A, Buklemishev Y Probl Endokrinol (Mosk). 2022; 68(1):81-93.

PMID: 35262299 DOI: 10.14341/probl12864.

Bone and Mineral Metabolism Phenotypes in MEN1-Related and Sporadic Primary Hyperparathyroidism, before and after Parathyroidectomy.

Marini F, Giusti F, Cioppi F, Maraghelli D, Cavalli T, Tonelli F Cells. 2021; 10(8).

PMID: 34440663 PMC: 8391385. DOI: 10.3390/cells10081895.

Editorial: Early Genetic and Clinical Diagnosis in MEN1.

Lourenco Jr D, de Herder W Front Endocrinol (Lausanne). 2020; 11:218.

PMID: 32351454 PMC: 7174644. DOI: 10.3389/fendo.2020.00218.

Outcome and long-term follow-up of adrenal lesions in multiple endocrine neoplasia type 1.

Ventura M, Melo M, Carrilho F Arch Endocrinol Metab. 2019; 63(5):516-523.

PMID: 31482957 PMC: 10522267. DOI: 10.20945/2359-3997000000170.

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