CD147 Expression in Advanced Cutaneous Squamous Cell Carcinoma

Overview

Journal J Cutan Pathol

Publisher Wiley

Specialty Dermatology

Date 2012 May 12

PMID 22575025

Citations 10

Authors

Larissa Sweeny

Nichole R Dean

John W Frederick

J Scott Magnuson

William R Carroll

Renee A Desmond

Eben L Rosenthal

Affiliations

Soon will be listed here.

Abstract

Background: CD147 is upregulated in multiple cancer types, but its expression in advanced cutaneous squamous cell carcinoma (SCC) is unknown. Our purpose was to evaluate the expression patterns of CD147 and related monocarboxylate transporters (MCT1, MCT4) to determine their correlation with survival.

Methods: This is a retrospective cohort study of patients with advanced stage cutaneous SCC of the head and neck who presented to a tertiary care center between 1998 and 2006 (n=50). CD147, MCT1 and MCT4 expression levels were assessed using immunofluorescence analysis of archived tumor samples and correlated with survival and clinicopathologic characteristics.

Results: The majority of patients (92%, n = 46) were diagnosed with stage III disease, with 46% (n = 23) having positive regional lymph node metastasis and 8% (n = 4) with distant metastasis. Primary malignancies had an overexpression of CD147 (78%; n = 35), MCT1 (23%; n = 10) and MCT4 (47%; n = 20). In addition, there was a significant relationship between the overexpression of CD147 and node positive disease (p = 0.048). Two- and five-year survival rates were 69 and 61%, respectively. There was a trend toward decreased survival in patients with overexpression of CD147 (p = 0.17), MCT1 (p = 0.11) and MCT4 (p = 0.15).

Conclusion: CD147 may represent a biomarker or potential therapeutic target in advanced cutaneous SCC.

Citing Articles

Proton-coupled monocarboxylate transporters in cancer: From metabolic crosstalk, immunosuppression and anti-apoptosis to clinical applications.

Duan Q, Zhang S, Wang Y, Lu D, Sun Y, Wu Y Front Cell Dev Biol. 2022; 10:1069555.

PMID: 36506099 PMC: 9727313. DOI: 10.3389/fcell.2022.1069555.

Oh, the Mutations You'll Acquire! A Systematic Overview of Cutaneous Squamous Cell Carcinoma.

Droll S, Bao X Cell Physiol Biochem. 2021; 55(S2):89-119.

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Extracellular matrix metalloproteinase inducer expression in histological grades of oral squamous cell carcinoma - An immunohistochemical study.

Khan S, Prakash N, Pradeep G, Mahajan A, Mokashi R, Patil R J Oral Maxillofac Pathol. 2021; 24(3):530-535.

PMID: 33967492 PMC: 8083423. DOI: 10.4103/jomfp.JOMFP_26_20.

Oxidative Stress and the Intersection of Oncogenic Signaling and Metabolism in Squamous Cell Carcinomas.

Choe J, Mazambani S, Kim T, Kim J Cells. 2021; 10(3).

PMID: 33803326 PMC: 8000417. DOI: 10.3390/cells10030606.

Prognostic value of glycolysis markers in head and neck squamous cell carcinoma: a meta-analysis.

Wang Y, Li Y, Jiang L, Ren X, Cheng B, Xia J Aging (Albany NY). 2021; 13(5):7284-7299.

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References

Koukourakis M, Giatromanolaki A, Harris A, Sivridis E . Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma. Cancer Res. 2006; 66(2):632-7. DOI: 10.1158/0008-5472.CAN-05-3260. View

Riethdorf S, Reimers N, Assmann V, Kornfeld J, Terracciano L, Sauter G . High incidence of EMMPRIN expression in human tumors. Int J Cancer. 2006; 119(8):1800-10. DOI: 10.1002/ijc.22062. View

Pinheiro C, Longatto-Filho A, Scapulatempo C, Ferreira L, Martins S, Pellerin L . Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas. Virchows Arch. 2008; 452(2):139-46. DOI: 10.1007/s00428-007-0558-5. View

Wahl M, Owen J, Burd R, Herlands R, Nogami S, Rodeck U . Regulation of intracellular pH in human melanoma: potential therapeutic implications. Mol Cancer Ther. 2002; 1(8):617-28. View

Lansbury L, Leonardi-Bee J, Perkins W, Goodacre T, Tweed J, Bath-Hextall F . Interventions for non-metastatic squamous cell carcinoma of the skin. Cochrane Database Syst Rev. 2010; (4):CD007869. PMC: 10816961. DOI: 10.1002/14651858.CD007869.pub2. View

Alam M, Ratner D . Cutaneous squamous-cell carcinoma. N Engl J Med. 2001; 344(13):975-83. DOI: 10.1056/NEJM200103293441306. View

Pinheiro C, Longatto-Filho A, Ferreira L, Pereira S, Etlinger D, Moreira M . Increasing expression of monocarboxylate transporters 1 and 4 along progression to invasive cervical carcinoma. Int J Gynecol Pathol. 2008; 27(4):568-74. DOI: 10.1097/PGP.0b013e31817b5b40. View

Pinheiro C, Longatto-Filho A, Pereira S, Etlinger D, Moreira M, Jube L . Monocarboxylate transporters 1 and 4 are associated with CD147 in cervical carcinoma. Dis Markers. 2009; 26(3):97-103. PMC: 3833680. DOI: 10.3233/DMA-2009-0596. View

Brizel D, Schroeder T, Scher R, Walenta S, Clough R, Dewhirst M . Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2001; 51(2):349-53. DOI: 10.1016/s0360-3016(01)01630-3. View

10.

Bordador L, Li X, Toole B, Chen B, Regezi J, Zardi L . Expression of emmprin by oral squamous cell carcinoma. Int J Cancer. 2000; 85(3):347-52. View

11.

Veness M . Treatment recommendations in patients diagnosed with high-risk cutaneous squamous cell carcinoma. Australas Radiol. 2005; 49(5):365-76. DOI: 10.1111/j.1440-1673.2005.01496.x. View

12.

Biswas C, Zhang Y, DeCastro R, Guo H, Nakamura T, Kataoka H . The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily. Cancer Res. 1995; 55(2):434-9. View

13.

Atkins D, Reiffen K, Tegtmeier C, Winther H, Bonato M, Storkel S . Immunohistochemical detection of EGFR in paraffin-embedded tumor tissues: variation in staining intensity due to choice of fixative and storage time of tissue sections. J Histochem Cytochem. 2004; 52(7):893-901. DOI: 10.1369/jhc.3A6195.2004. View

14.

Gallagher S, Castorino J, Wang D, Philp N . Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231. Cancer Res. 2007; 67(9):4182-9. DOI: 10.1158/0008-5472.CAN-06-3184. View

15.

Tang Y, Nakada M, Kesavan P, McCabe F, Millar H, Rafferty P . Extracellular matrix metalloproteinase inducer stimulates tumor angiogenesis by elevating vascular endothelial cell growth factor and matrix metalloproteinases. Cancer Res. 2005; 65(8):3193-9. DOI: 10.1158/0008-5472.CAN-04-3605. View

16.

Tang Y, Nakada M, Rafferty P, Laraio J, McCabe F, Millar H . Regulation of vascular endothelial growth factor expression by EMMPRIN via the PI3K-Akt signaling pathway. Mol Cancer Res. 2006; 4(6):371-7. DOI: 10.1158/1541-7786.MCR-06-0042. View

17.

Philp N, Ochrietor J, Rudoy C, Muramatsu T, Linser P . Loss of MCT1, MCT3, and MCT4 expression in the retinal pigment epithelium and neural retina of the 5A11/basigin-null mouse. Invest Ophthalmol Vis Sci. 2003; 44(3):1305-11. DOI: 10.1167/iovs.02-0552. View

18.

Rosenthal E, Shreenivas S, Peters G, Grizzle W, Desmond R, Gladson C . Expression of extracellular matrix metalloprotease inducer in laryngeal squamous cell carcinoma. Laryngoscope. 2003; 113(8):1406-10. DOI: 10.1097/00005537-200308000-00027. View

19.

Ishibashi Y, Matsumoto T, Niwa M, Suzuki Y, Omura N, Hanyu N . CD147 and matrix metalloproteinase-2 protein expression as significant prognostic factors in esophageal squamous cell carcinoma. Cancer. 2004; 101(9):1994-2000. DOI: 10.1002/cncr.20593. View

20.

Fukumura D, Xu L, Chen Y, Gohongi T, Seed B, Jain R . Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo. Cancer Res. 2001; 61(16):6020-4. View