Enhanced Antiviral Activity of Acyclovir Loaded into Nanoparticles

Overview

Journal Methods Enzymol

Specialty Biochemistry

Date 2012 May 10

PMID 22568898

Citations 13

Authors

Roberta Cavalli

Manuela Donalisio

Agnese Bisazza

Andrea Civra

Elisabetta Ranucci

Paolo Ferruti

David Lembo

Affiliations

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Abstract

The activity of antivirals can be enhanced by their incorporation in nanoparticulate delivery systems. Peculiar polymeric nanoparticles, based on a β-cyclodextrin-poly(4-acryloylmorpholine) monoconjugate (β-CD-PACM), are proposed as acyclovir carriers. The experimental procedure necessary to obtain the acyclovir-loaded nanoparticles using the solvent displacement preparation method will be described in this chapter. Fluorescent labeled nanoparticles are prepared using the same method for cellular trafficking studies. The biocompatibility assays necessary to obtain safe nanoparticles are reported. Section 4 of this chapter describes the assessment of the antiviral activity of the acyclovir-loaded nanoparticles.

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