Inflammation and Oxidative Stress in Obesity-related Glomerulopathy

Overview

Journal Int J Nephrol

Publisher Wiley

Specialty Nephrology

Date 2012 May 9

PMID 22567283

Citations 39

Authors

Jinhua Tang

Haidong Yan

Shougang Zhuang

Affiliations

Soon will be listed here.

Abstract

Obesity-related glomerulopathy is an increasing cause of end-stage renal disease. Obesity has been considered a state of chronic low-grade systemic inflammation and chronic oxidative stress. Augmented inflammation in adipose and kidney tissues promotes the progression of kidney damage in obesity. Adipose tissue, which is accumulated in obesity, is a key endocrine organ that produces multiple biologically active molecules, including leptin, adiponectin, resistin, that affect inflammation, and subsequent deregulation of cell function in renal glomeruli that leads to pathological changes. Oxidative stress is also associated with obesity-related renal diseases and may trigger the initiation or progression of renal damage in obesity. In this paper, we focus on inflammation and oxidative stress in the progression of obesity-related glomerulopathy and possible interventions to prevent kidney injury in obesity.

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