Comparison of Adenosine Deaminase Levels in Serum and Synovial Fluid Between Patients with Rheumatoid Arthritis and Osteoarthritis

Overview

Journal Int J Clin Exp Med

Specialty General Medicine

Date 2012 May 9

PMID 22567181

Citations 11

Authors

Zahra Zakeri

Shahrokh Izadi

Abassali Niazi

Zohre Bari

Soodabeh Zendeboodi

Mansoor Shakiba

Mohammadali Mashhadi

Behzad Narouie

Mohammad Ghasemi-Rad

Affiliations

Soon will be listed here.

Abstract

Objectives: Adenosine deaminase (ADA) is an enzyme being involved in purine metabolism and plays a significant role in the immune system. The aim of this study was to investigate the use of adenosine deaminase levels in differentiating between rheumatoid arthritis and osteoarthritis.

Material And Methods: Thirty patients with rheumatoid arthritis and 30 osteoarthritis patients enrolled the study. They were matched in sex and age. Using the ROC curve, we determined the optimal serum and synovial cutoff for rheumatoid effusion.

Results: The results showed a statistically significant difference between ADA levels in joint effusion and serum of patients with rheumatoid arthritis and osteoarthritis (p<0.001). Synovial fluid cutoff value for diagnosing rheumatoid arthritis was 20 with a sensitivity of 90% and specificity of 80% and the serum cutoff value was 15 with a sensitivity of 93% and specificity of 53.3%. Area under ROC curve for synovial ADA, ESR and CRP co-linearity was 99%.

Conclusion: We concluded that synovial total ADA assay can be a sensitive and specific test, being suitable for rapid diagnosis of rheumatoid effusions.

Citing Articles

Comparison of Adenosine Deaminase, C-reactive Protein, Uric Acid, and Rheumatoid Arthritis Levels in Patients With Rheumatoid Arthritis and Those Without Arthritis: A Review.

Makhe P, Vagga A Cureus. 2024; 16(4):e57433.

PMID: 38699124 PMC: 11063568. DOI: 10.7759/cureus.57433.

Anti-Inflammatory Effects of Endogenously Released Adenosine in Synovial Cells of Osteoarthritis and Rheumatoid Arthritis Patients.

Sohn R, Junker M, Meurer A, Zaucke F, Straub R, Jenei-Lanzl Z Int J Mol Sci. 2021; 22(16).

PMID: 34445661 PMC: 8396606. DOI: 10.3390/ijms22168956.

Purinergic System Signaling in Metainflammation-Associated Osteoarthritis.

Gratal P, Lamuedra A, Medina J, Bermejo-Alvarez I, Largo R, Herrero-Beaumont G Front Med (Lausanne). 2020; 7:506.

PMID: 32984382 PMC: 7485330. DOI: 10.3389/fmed.2020.00506.

Purinergic Signalling: Therapeutic Developments.

Burnstock G Front Pharmacol. 2017; 8:661.

PMID: 28993732 PMC: 5622197. DOI: 10.3389/fphar.2017.00661.

Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers.

Brown P, Pratt A, Isaacs J Nat Rev Rheumatol. 2016; 12(12):731-742.

PMID: 27784891 DOI: 10.1038/nrrheum.2016.175.

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