The Sensitivity of Schistosoma Japonicum to Praziquantel: a Field Evaluation in Areas with Low Endemicity of China

Overview

Journal Am J Trop Med Hyg

Specialty Tropical Medicine

Date 2012 May 5

PMID 22556083

Citations 11

Authors

Wei Wang

Jian-Rong Dai

Hong-Jun Li

Xue-hui Shen

You-Sheng Liang

Affiliations

Soon will be listed here.

Abstract

The purpose of the current study was to investigate the susceptibility of Schistosoma japonicum to praziquantel in low endemic foci of China. During the non-transmission period of schistosomiasis, a total of 43 of 1,242 subjects were identified as being infected with the parasite using parasitological stool examinations in two low-endemicity areas of China, with a prevalence rate of 3.46%. All stool-egg-positive subjects were treated with praziquantel in a single oral dose of 40 mg/kg or 30 mg/kg for two successive days. Six weeks post-treatment, no S. japonicum eggs were detected in the 43 treated villagers. The results indicate that the current efficacy of praziquantel against S. japonicum seems satisfactory and has not changed over the past three decades in the low endemic areas of China. It is also suggested that no evidence of tolerance or resistance to praziquantel in S. japonicum is detected in areas with low endemicity in China.

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References

Fallon P, Doenhoff M . Drug-resistant schistosomiasis: resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific. Am J Trop Med Hyg. 1994; 51(1):83-8. DOI: 10.4269/ajtmh.1994.51.83. View

Yu J, de Vlas S, Jiang Q, Gryseels B . Comparison of the Kato-Katz technique, hatching test and indirect hemagglutination assay (IHA) for the diagnosis of Schistosoma japonicum infection in China. Parasitol Int. 2006; 56(1):45-9. DOI: 10.1016/j.parint.2006.11.002. View

Balen J, Zhao Z, Williams G, McManus D, Raso G, Utzinger J . Prevalence, intensity and associated morbidity of Schistosoma japonicum infection in the Dongting Lake region, China. Bull World Health Organ. 2007; 85(7):519-26. PMC: 2636368. DOI: 10.2471/blt.06.034033. View

Zhu Y . Immunodiagnosis and its role in schistosomiasis control in China: a review. Acta Trop. 2005; 96(2-3):130-6. DOI: 10.1016/j.actatropica.2005.07.007. View

Zhou X, Wang L, Chen M, Wu X, Jiang Q, Chen X . The public health significance and control of schistosomiasis in China--then and now. Acta Trop. 2005; 96(2-3):97-105. DOI: 10.1016/j.actatropica.2005.07.005. View

GONNERT R, Andrews P . Praziquantel, a new board-spectrum antischistosomal agent. Z Parasitenkd. 1977; 52(2):129-50. DOI: 10.1007/BF00389899. View

Alonso D, Munoz J, Gascon J, Valls M, Corachan M . Failure of standard treatment with praziquantel in two returned travelers with Schistosoma haematobium infection. Am J Trop Med Hyg. 2006; 74(2):342-4. View

Xiao S, Keiser J, Chen M, Tanner M, Utzinger J . Research and development of antischistosomal drugs in the People's Republic of China a 60-year review. Adv Parasitol. 2010; 73:231-95. DOI: 10.1016/S0065-308X(10)73009-8. View

Chen M . Use of praziquantel for clinical treatment and morbidity control of schistosomiasis japonica in China: a review of 30 years' experience. Acta Trop. 2005; 96(2-3):168-76. DOI: 10.1016/j.actatropica.2005.07.011. View

10.

Lin D, Liu J, Liu Y, Hu F, Zhang Y, Xu J . Routine Kato-Katz technique underestimates the prevalence of Schistosoma japonicum: a case study in an endemic area of the People's Republic of China. Parasitol Int. 2008; 57(3):281-6. DOI: 10.1016/j.parint.2008.04.005. View

11.

Wang W, Dai J, Li H, Shen X, Liang Y . Is there reduced susceptibility to praziquantel in Schistosoma japonicum? Evidence from China. Parasitology. 2010; 137(13):1905-12. DOI: 10.1017/S0031182010001204. View

12.

. Prevention and control of schistosomiasis and soil-transmitted helminthiasis. World Health Organ Tech Rep Ser. 2003; 912:i-vi, 1-57, back cover. View

13.

Wang L, Utzinger J, Zhou X . Schistosomiasis control: experiences and lessons from China. Lancet. 2008; 372(9652):1793-5. PMC: 7135384. DOI: 10.1016/S0140-6736(08)61358-6. View

14.

Fallon P, Sturrock R, Niang A, Doenhoff M . Short report: diminished susceptibility to praziquantel in a Senegal isolate of Schistosoma mansoni. Am J Trop Med Hyg. 1995; 53(1):61-2. View

15.

Zhou X, Guo J, Wu X, Jiang Q, Zheng J, Dang H . Epidemiology of schistosomiasis in the People's Republic of China, 2004. Emerg Infect Dis. 2008; 13(10):1470-6. PMC: 2851518. DOI: 10.3201/eid1310.061423. View

16.

Katz N, Chaves A, Pellegrino J . A simple device for quantitative stool thick-smear technique in Schistosomiasis mansoni. Rev Inst Med Trop Sao Paulo. 1972; 14(6):397-400. View

17.

Liang Y, Dai J, Ning A, Yu D, Xu X, Zhu Y . Susceptibility of Schistosoma japonicum to praziquantel in China. Trop Med Int Health. 2001; 6(9):707-14. DOI: 10.1046/j.1365-3156.2001.00772.x. View

18.

Engels D, Chitsulo L, Montresor A, Savioli L . The global epidemiological situation of schistosomiasis and new approaches to control and research. Acta Trop. 2002; 82(2):139-46. PMC: 5633073. DOI: 10.1016/s0001-706x(02)00045-1. View

19.

Xianyi C, Liying W, Jiming C, Xiaonong Z, Jiang Z, Jiagang G . Schistosomiasis control in China: the impact of a 10-year World Bank Loan Project (1992-2001). Bull World Health Organ. 2005; 83(1):43-8. PMC: 2623468. DOI: /S0042-96862005000100013. View

20.

Yu D, Li Y, Sleigh A, Yu X, Li Y, Wei W . Efficacy of praziquantel against Schistosoma japonicum: field evaluation in an area with repeated chemotherapy compared with a newly identified endemic focus in Hunan, China. Trans R Soc Trop Med Hyg. 2001; 95(5):537-41. DOI: 10.1016/s0035-9203(01)90032-x. View