Genetics and Evolution of Hybrid Male Sterility in House Mice

Overview

Journal Genetics

Publisher Oxford University Press

Specialty Genetics

Date 2012 May 5

PMID 22554891

Citations 45

Authors

Michael A White

Maria Stubbings

Beth L Dumont

Bret A Payseur

Affiliations

Soon will be listed here.

Abstract

Comparative genetic mapping provides insights into the evolution of the reproductive barriers that separate closely related species. This approach has been used to document the accumulation of reproductive incompatibilities over time, but has only been applied to a few taxa. House mice offer a powerful system to reconstruct the evolution of reproductive isolation between multiple subspecies pairs. However, studies of the primary reproductive barrier in house mice-hybrid male sterility-have been restricted to a single subspecies pair: Mus musculus musculus and Mus musculus domesticus. To provide a more complete characterization of reproductive isolation in house mice, we conducted an F(2) intercross between wild-derived inbred strains from Mus musculus castaneus and M. m. domesticus. We identified autosomal and X-linked QTL associated with a range of hybrid male sterility phenotypes, including testis weight, sperm density, and sperm morphology. The pseudoautosomal region (PAR) was strongly associated with hybrid sterility phenotypes when heterozygous. We compared QTL found in this cross with QTL identified in a previous F(2) intercross between M. m. musculus and M. m. domesticus and found three shared autosomal QTL. Most QTL were not shared, demonstrating that the genetic basis of hybrid male sterility largely differs between these closely related subspecies pairs. These results lay the groundwork for identifying genes responsible for the early stages of speciation in house mice.

Citing Articles

Different complex regulatory phenotypes underlie hybrid male sterility in divergent rodent crosses.

Hunnicutt K, Callahan C, Callahan C, Keeble S, Moore E, Good J Genetics. 2024; 229(2).

PMID: 39601270 PMC: 11796465. DOI: 10.1093/genetics/iyae198.

A Minimal Hybrid Sterility Genome Assembled by Chromosome Swapping Between Mouse Subspecies (Mus musculus).

Fotopulosova V, Tanieli G, Fusek K, Jansa P, Forejt J Mol Biol Evol. 2024; 41(10).

PMID: 39404090 PMC: 11518865. DOI: 10.1093/molbev/msae211.

Identification and genetic analysis of a pervasive 'needle-eye' sperm phenotype in sterile hybrid males.

Kanippayoor R, Soeder C, Hsiang T, Jones C, Moehring A Proc Biol Sci. 2024; 291(2025):20240483.

PMID: 38889778 PMC: 11286126. DOI: 10.1098/rspb.2024.0483.

Into the Wild: A novel wild-derived inbred strain resource expands the genomic and phenotypic diversity of laboratory mouse models.

Dumont B, Gatti D, Ballinger M, Lin D, Phifer-Rixey M, Sheehan M PLoS Genet. 2024; 20(4):e1011228.

PMID: 38598567 PMC: 11034653. DOI: 10.1371/journal.pgen.1011228.

Inference of selective forces on house mouse genomes during secondary contact in East Asia.

Fujiwara K, Kubo S, Endo T, Takada T, Shiroishi T, Suzuki H Genome Res. 2024; 34(3):366-375.

PMID: 38508692 PMC: 11067880. DOI: 10.1101/gr.278828.123.

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