Genetics of Xenotropic Virus Expression in Mice. I. Evidence for a Single Locus Regulating Spontaneous Production of Infectious Virus in Crosses Involving NZB/B1NJ and 129/J Strains of Mice

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1979 Jun 1

PMID 225542

Citations 1

Authors

J A Levy

J Joyner

K T Nayar

R E Kouri

Affiliations

Soon will be listed here.

Abstract

The extent of infectious xenotropic virus expression in homogenized splenic tissues from the high-virus-expressing NZB/BINJ mice and the non-virus-expressing 129/J mice and their crosses has been examined. The data suggest that a single autosomal "dominant-like" gene controls the spontaneous production and release of infectious xenotropic virus in NZB mice. Analysis of infectious virus production in second-backcross families [(F1 X 129) X 129] confirmed this conclusion. Variations in the amount of X-tropic virus released were evident in all genetic crosses. Virus titers (expressed as focus-forming units per milliliter) of supernatant fluid ranged from high levels in the NZB mice to somewhat lower levels in crosses involving the 129 mice. In the absence of a definite pattern in the titers observed in the genetic crosses studied, the term dominant-like is proposed for the single gene regulating the expression of X-tropic virus in NZB mice.

Citing Articles

Lipopolysaccharide induces retroviral antigen expression in 129/J mouse lymphocytes: evidence for assembly of a defective viral particle.

Jongstra J, Moroni C J Virol. 1981; 37(3):1044-50.

PMID: 6164797 PMC: 171101. DOI: 10.1128/JVI.37.3.1044-1050.1981.

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