Effect of Pretreatment Clinical Factors on Overall Survival in Glioblastoma Multiforme: a Surveillance Epidemiology and End Results (SEER) Population Analysis

Overview

Journal World J Surg Oncol

Publisher Biomed Central

Specialties General Surgery
Oncology

Date 2012 May 5

PMID 22553975

Citations 28

Authors

Sudheer R Thumma

Robert K Fairbanks

Wayne T Lamoreaux

Alexander R Mackay

John J Demakas

Barton S Cooke

Ameer L Elaimy

Peter W Hanson

Christopher M Lee

Affiliations

Soon will be listed here.

Abstract

Background: Glioblastoma Multiforme (GBM) is one of the most aggressive primary brain tumors and is associated with a dismal prognosis. The median survival after the primary diagnosis remains poor, even after multimodal treatment approaches. However, a few patients have been reported to have long term survival greater than three years. A number of studies have attempted to define factors capable of predicting long term outcomes in specific patient groups. This article reports the outcomes of a very large group of patients diagnosed with GBM, and analyzes specific prognostic factors known to influence survival in these patients.

Methods: We used the Surveillance, Epidemiology, and End Results (SEER) database of the US National Cancer Institute (NCI) to investigate various patient-related and treatment-related factors that could influence the long term survival in patients diagnosed with glioblastoma. A total of 34,664 patients aged 20 years or older with a diagnosis of GBM during the years 1973 to 2008 were studied. Overall survival outcomes were examined with Kaplan-Meier survival analysis and Cox hazard models.

Results: Asian/Pacific Islanders had a better survival compared to the white population (P = <0.001). Patients diagnosed with GBM during the years 2000 to 2008 had a superior survival rate when compared with earlier decades (P = <0 .001). Statistically significant improvements in overall survival were also found for patients who received surgical resections, and adjuvant radiation treatment versus no radiation (P-values <0.001). Young age was also found to be highly predictive of improved overall survival rates when separated into age groups as well as when studied as a continuous variable.

Conclusions: Clinical pretreatment and treatment factors, including young age at diagnosis, Asian/Pacific Islander ethnicity, recent year of diagnosis, surgical resection and the use of adjuvant radiation therapy favorably influence survival in patients diagnosed with glioblastoma.

Trial Registration: All data were obtained from the United States Surveillance Epidemiology and End Results (SEER) database.

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References

Scott J, Rewcastle N, Brasher P, Fulton D, Mackinnon J, Hamilton M . Which glioblastoma multiforme patient will become a long-term survivor? A population-based study. Ann Neurol. 1999; 46(2):183-8. View

Darefsky A, King Jr J, Dubrow R . Adult glioblastoma multiforme survival in the temozolomide era: a population-based analysis of Surveillance, Epidemiology, and End Results registries. Cancer. 2011; 118(8):2163-72. PMC: 3235223. DOI: 10.1002/cncr.26494. View

Ohgaki H, Dessen P, Jourde B, Horstmann S, Nishikawa T, Di Patre P . Genetic pathways to glioblastoma: a population-based study. Cancer Res. 2004; 64(19):6892-9. DOI: 10.1158/0008-5472.CAN-04-1337. View

Sano T, Lin H, Chen X, Langford L, Koul D, Bondy M . Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis. Cancer Res. 1999; 59(8):1820-4. View

Patel M, Siddiqui F, Jin J, Mikkelsen T, Rosenblum M, Movsas B . Salvage reirradiation for recurrent glioblastoma with radiosurgery: radiographic response and improved survival. J Neurooncol. 2008; 92(2):185-91. DOI: 10.1007/s11060-008-9752-9. View

Oszvald A, Guresir E, Setzer M, Vatter H, Senft C, Seifert V . Glioblastoma therapy in the elderly and the importance of the extent of resection regardless of age. J Neurosurg. 2011; 116(2):357-64. DOI: 10.3171/2011.8.JNS102114. View

Valery C, Seilhean D, Boyer O, Marro B, Hauw J, Kemeny J . Long-term survival after gene therapy for a recurrent glioblastoma. Neurology. 2002; 58(7):1109-12. DOI: 10.1212/wnl.58.7.1109. View

Sanai N, Polley M, McDermott M, Parsa A, Berger M . An extent of resection threshold for newly diagnosed glioblastomas. J Neurosurg. 2011; 115(1):3-8. DOI: 10.3171/2011.2.jns10998. View

Barnholtz-Sloan J, Sloan A, Schwartz A . Relative survival rates and patterns of diagnosis analyzed by time period for individuals with primary malignant brain tumor, 1973-1997. J Neurosurg. 2003; 99(3):458-66. DOI: 10.3171/jns.2003.99.3.0458. View

10.

Asthagiri A, Pouratian N, Sherman J, Ahmed G, Shaffrey M . Advances in brain tumor surgery. Neurol Clin. 2007; 25(4):975-1003, viii-ix. DOI: 10.1016/j.ncl.2007.07.006. View

11.

Chandler K, PRADOS M, Malec M, Wilson C . Long-term survival in patients with glioblastoma multiforme. Neurosurgery. 1993; 32(5):716-20; discussion 720. DOI: 10.1227/00006123-199305000-00003. View

12.

Krex D, Klink B, Hartmann C, von Deimling A, Pietsch T, Simon M . Long-term survival with glioblastoma multiforme. Brain. 2007; 130(Pt 10):2596-606. DOI: 10.1093/brain/awm204. View

13.

Gil-Benso R, Lopez-Gines C, Benito R, Lopez-Guerrero J, Callaghan R, Pellin A . Concurrent EGFR amplification and TP-53 mutation in glioblastomas. Clin Neuropathol. 2007; 26(5):224-31. DOI: 10.5414/npp26224. View

14.

Curran Jr W, Scott C, Horton J, Nelson J, Weinstein A, Fischbach A . Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials. J Natl Cancer Inst. 1993; 85(9):704-10. DOI: 10.1093/jnci/85.9.704. View

15.

Sabel M, Reifenberger J, Weber R, Reifenberger G, Schmitt H . Long-term survival of a patient with giant cell glioblastoma. Case report. J Neurosurg. 2001; 94(4):605-11. DOI: 10.3171/jns.2001.94.4.0605. View

16.

Robertson J, Gunter B, Somes G . Racial differences in the incidence of gliomas: a retrospective study from Memphis, Tennessee. Br J Neurosurg. 2003; 16(6):562-6. View

17.

Sneed P, PRADOS M, McDermott M, Larson D, Malec M, Lamborn K . Large effect of age on the survival of patients with glioblastoma treated with radiotherapy and brachytherapy boost. Neurosurgery. 1995; 36(5):898-903; discussion 903-4. DOI: 10.1227/00006123-199505000-00002. View

18.

Romanelli P, Conti A, Pontoriero A, Ricciardi G, Tomasello F, De Renzis C . Role of stereotactic radiosurgery and fractionated stereotactic radiotherapy for the treatment of recurrent glioblastoma multiforme. Neurosurg Focus. 2009; 27(6):E8. DOI: 10.3171/2009.9.FOCUS09187. View

19.

Das A, Tan W, Teo J, Smith D . Glioblastoma multiforme in an Asian population: evidence for a distinct genetic pathway. J Neurooncol. 2003; 60(2):117-25. DOI: 10.1023/a:1020622415786. View

20.

Scoccianti S, Magrini S, Ricardi U, Detti B, Buglione M, Sotti G . Patterns of care and survival in a retrospective analysis of 1059 patients with glioblastoma multiforme treated between 2002 and 2007: a multicenter study by the Central Nervous System Study Group of Airo (italian Association of Radiation Oncology). Neurosurgery. 2010; 67(2):446-58. DOI: 10.1227/01.NEU.0000371990.86656.E8. View