Genetically Engineered Immune Privileged Sertoli Cells: A New Road to Cell Based Gene Therapy

Overview

Journal Spermatogenesis

Date 2012 May 4

PMID 22553487

Citations 15

Authors

Gurvinder Kaur

Charles R Long

Jannette M Dufour

Affiliations

Soon will be listed here.

Abstract

Sertoli cells are immune privileged cells, important for controlling the immune response to male germ cells as well as maintaining the tolerogenic environment in the testis. Additionally, ectopic Sertoli cells have been shown to survive and protect co-grafted cells when transplanted across immunological barriers. The survival of ectopic Sertoli cells has led to the idea that they could be used in cell based gene therapy. In this review, we provide a brief overview of testis immune privilege and Sertoli cell transplantation, factors contributing to Sertoli cell immune privilege, the challenges faced by viral vector gene therapy, the use of immune privileged cells in cell based gene therapy and describe several recent studies on the use of genetically engineered Sertoli cells to provide continuous delivery of therapeutic proteins.

Citing Articles

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Microencapsulated Sertoli cells sustain myoblast proliferation without affecting the myogenic potential. data.

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