Spherical Harmonic Analysis of Cortical Complexity in Autism and Dyslexia

Overview

Journal Transl Neurosci

Specialty Neurology

Date 2012 May 1

PMID 22545198

Citations 8

Authors

Emily L Williams

Ayman El-Baz

Matthew Nitzken

Andrew E Switala

Manuel F Casanova

Affiliations

Soon will be listed here.

Abstract

Alterations in gyral form and complexity have been consistently noted in both autism and dyslexia. In this present study, we apply spherical harmonics, an established technique which we have exapted to estimate surface complexity of the brain, in order to identify abnormalities in gyrification between autistics, dyslexics, and controls. On the order of absolute surface complexity, autism exhibits the most extreme phenotype, controls occupy the intermediate ranges, and dyslexics exhibit lesser surface complexity. Here, we synthesize our findings which demarcate these three groups and review how factors controlling neocortical proliferation and neuronal migration may lead to these distinctive phenotypes.

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