Effect of Mindfulness Training on Asthma Quality of Life and Lung Function: a Randomised Controlled Trial

Overview

Journal Thorax

Date 2012 May 1

PMID 22544892

Citations 43

Authors

Lori Pbert

J Mark Madison

Susan Druker

Nicholas Olendzki

Robert Magner

George Reed

Jeroan Allison

James Carmody

Affiliations

Soon will be listed here.

Abstract

Background: This study evaluated the efficacy of a mindfulness training programme (mindfulness-based stress reduction (MBSR)) in improving asthma-related quality of life and lung function in patients with asthma.

Methods: A randomised controlled trial compared an 8-week MBSR group-based programme (n=42) with an educational control programme (n=41) in adults with mild, moderate or severe persistent asthma recruited at a university hospital outpatient primary care and pulmonary care clinic. Primary outcomes were quality of life (Asthma Quality of Life Questionnaire) and lung function (change from baseline in 2-week average morning peak expiratory flow (PEF)). Secondary outcomes were asthma control assessed by 2007 National Institutes of Health/National Heart Lung and Blood Institute guidelines, and stress (Perceived Stress Scale (PSS)). Follow-up assessments were conducted at 10 weeks, 6 and 12 months.

Results: At 12 months MBSR resulted in clinically significant improvements from baseline in quality of life (differential change in Asthma Quality of Life Questionnaire score for MBSR vs control: 0.66 (95% CI 0.30 to 1.03; p<0.001)) but not in lung function (morning PEF, PEF variability and forced expiratory volume in 1 s). MBSR also resulted in clinically significant improvements in perceived stress (differential change in PSS score for MBSR vs control: -4.5 (95% CI -7.1 to -1.9; p=0.001)). There was no significant difference (p=0.301) in percentage of patients in MBSR with well controlled asthma (7.3% at baseline to 19.4%) compared with the control condition (7.5% at baseline to 7.9%).

Conclusions: MBSR produced lasting and clinically significant improvements in asthma-related quality of life and stress in patients with persistent asthma, without improvements in lung function.

Clinical Trial Registration Number: Asthma and Mindfulness-Based Reduction (MBSR) Identifier: NCT00682669. clinicaltrials.gov.

Citing Articles

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Higgins E, Davidson R, Busse W, Klaus D, Bednarek G, Goldman R Brain Behav Immun Health. 2022; 25:100509.

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Mindfulness-Based Stress Reduction for Coronary Artery Disease Patients: Potential Improvements in Mastery and Depressive Symptoms.

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PMID: 33428638 PMC: 7799782. DOI: 10.1371/journal.pone.0244847.

References

Markham A, Wilkinson J . Complementary and alternative medicines (CAM) in the management of asthma: an examination of the evidence. J Asthma. 2004; 41(2):131-9. DOI: 10.1081/jas-120028581. View

Holgate S, Chuchalin A, Hebert J, Lotvall J, Persson G, Chung K . Efficacy and safety of a recombinant anti-immunoglobulin E antibody (omalizumab) in severe allergic asthma. Clin Exp Allergy. 2004; 34(4):632-8. DOI: 10.1111/j.1365-2222.2004.1916.x. View

Wisnivesky J, Lorenzo J, Feldman J, Leventhal H, Halm E . The relationship between perceived stress and morbidity among adult inner-city asthmatics. J Asthma. 2010; 47(1):100-4. DOI: 10.3109/02770900903426989. View

Rietveld S . Symptom perception in asthma: a multidisciplinary review. J Asthma. 1998; 35(2):137-46. DOI: 10.3109/02770909809068201. View

Boulet L, Bateman E, Voves R, Muller T, Wolf S, Engelstatter R . A randomized study comparing ciclesonide and fluticasone propionate in patients with moderate persistent asthma. Respir Med. 2007; 101(8):1677-86. DOI: 10.1016/j.rmed.2007.03.001. View

Ross C, Davis T, MacDonald G . Cognitive-behavioral treatment combined with asthma education for adults with asthma and coexisting panic disorder. Clin Nurs Res. 2005; 14(2):131-57. DOI: 10.1177/1054773804273863. View

Kullowatz A, Rosenfield D, Dahme B, Magnussen H, Kanniess F, Ritz T . Stress effects on lung function in asthma are mediated by changes in airway inflammation. Psychosom Med. 2008; 70(4):468-75. DOI: 10.1097/PSY.0b013e31816f9c2f. View

Roth B, Robbins D . Mindfulness-based stress reduction and health-related quality of life: findings from a bilingual inner-city patient population. Psychosom Med. 2004; 66(1):113-23. DOI: 10.1097/01.psy.0000097337.00754.09. View

Yorke J, Fleming S, Shuldham C . Psychological interventions for adults with asthma: a systematic review. Respir Med. 2006; 101(1):1-14. DOI: 10.1016/j.rmed.2006.04.003. View

10.

Juniper E, Guyatt G, Willan A, Griffith L . Determining a minimal important change in a disease-specific Quality of Life Questionnaire. J Clin Epidemiol. 1994; 47(1):81-7. DOI: 10.1016/0895-4356(94)90036-1. View

11.

. Standardization of Spirometry, 1994 Update. American Thoracic Society. Am J Respir Crit Care Med. 1995; 152(3):1107-36. DOI: 10.1164/ajrccm.152.3.7663792. View

12.

Cohen S, Kamarck T, Mermelstein R . A global measure of perceived stress. J Health Soc Behav. 1983; 24(4):385-96. View

13.

Leidy N, Coughlin C . Psychometric performance of the Asthma Quality of Life Questionnaire in a US sample. Qual Life Res. 1998; 7(2):127-34. DOI: 10.1023/a:1008853325724. View

14.

Janssens T, Verleden G, De Peuter S, Van Diest I, Van den Bergh O . Inaccurate perception of asthma symptoms: a cognitive-affective framework and implications for asthma treatment. Clin Psychol Rev. 2009; 29(4):317-27. DOI: 10.1016/j.cpr.2009.02.006. View

15.

Reddel H, Taylor D, Bateman E, Boulet L, Boushey H, Busse W . An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med. 2009; 180(1):59-99. DOI: 10.1164/rccm.200801-060ST. View

16.

Castro M, Rubin A, Laviolette M, Fiterman J, De Andrade Lima M, Shah P . Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. Am J Respir Crit Care Med. 2009; 181(2):116-24. PMC: 3269231. DOI: 10.1164/rccm.200903-0354OC. View

17.

Lemmens K, Nieboer A, Huijsman R . A systematic review of integrated use of disease-management interventions in asthma and COPD. Respir Med. 2009; 103(5):670-91. DOI: 10.1016/j.rmed.2008.11.017. View

18.

Ludwig D, Kabat-Zinn J . Mindfulness in medicine. JAMA. 2008; 300(11):1350-2. DOI: 10.1001/jama.300.11.1350. View

19.

Huntley A, White A, Ernst E . Relaxation therapies for asthma: a systematic review. Thorax. 2002; 57(2):127-31. PMC: 1746244. DOI: 10.1136/thorax.57.2.127. View