Adenosine is a Sensitive Oxygen Sensor in the Heart

Overview

Journal Experientia

Specialty Science

Date 1990 Dec 1

PMID 2253717

Citations 4

Authors

J Schrader

A Deussen

R T Smolenski

Affiliations

Soon will be listed here.

Abstract

Cardiac adenosine is formed both by an oxygen-sensitive (AMP----adenosine) and by an oxygen-insensitive (S-adenosylhomocysteine----adenosine) pathway. The phasic adenosine release during beta-adrenergic stimulation with isoproterenol is closely linked to coronary venous PO2 (isolated heart) and can be almost fully prevented when diastolic aortic pressure is maintained constant (heart in situ). During pressure autoregulation the transmural gradient of free adenosine is only increased when the autoregulatory reserve is exhausted. The critical PO2 below which adenosine formation is enhanced was found to be 3 mm Hg (isolated cardiomyocytes). Collectively, these data indicate that the formation of adenosine is not primarily coupled to the energy expenditure of the heart but to the supply/demand ratio for oxygen.

Citing Articles

Mortality Prediction by Kinetic Parameters of Lactate and S-Adenosylhomocysteine in a Cohort of Critically Ill Patients.

Schoettler J, Brohm K, Mindt S, Jager E, Hahn B, Fuderer T Int J Mol Sci. 2024; 25(12).

PMID: 38928097 PMC: 11204002. DOI: 10.3390/ijms25126391.

S-Adenosylhomocysteine Is a Useful Metabolic Factor in the Early Prediction of Septic Disease Progression and Death in Critically Ill Patients: A Prospective Cohort Study.

Centner F, Schoettler J, Brohm K, Mindt S, Jager E, Hahn B Int J Mol Sci. 2023; 24(16).

PMID: 37628779 PMC: 10454796. DOI: 10.3390/ijms241612600.

Adenosine and adenosine receptor-mediated action in coronary microcirculation.

Zhang Y, Wernly B, Cao X, Mustafa S, Tang Y, Zhou Z Basic Res Cardiol. 2021; 116(1):22.

PMID: 33755785 PMC: 7987637. DOI: 10.1007/s00395-021-00859-7.

Hyperoxia During Exercise: Impact on Adenosine Plasma Levels and Hemodynamic Data.

Boussuges A, Rives S, Marlinge M, Chaumet G, Vallee N, Guieu R Front Physiol. 2020; 11:97.

PMID: 32116800 PMC: 7026462. DOI: 10.3389/fphys.2020.00097.

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