Bone Regeneration in Artificial Jaw Cleft by Use of Carbonated Hydroxyapatite Particles and Mesenchymal Stem Cells Derived from Iliac Bone

Overview

Journal Int J Dent

Publisher Wiley

Specialty Dentistry

Date 2012 Apr 27

PMID 22536240

Citations 13

Authors

Motoko Yoshioka

Kotaro Tanimoto

Yuki Tanne

Keisuke Sumi

Tetsuya Awada

Nanae Oki

Masaru Sugiyama

Yukio Kato

Kazuo Tanne

Affiliations

Soon will be listed here.

Abstract

Objectives of the Study. Cleft lip and palate (CLP) is a prevalent congenital anomaly in the orofacial region. Autogenous iliac bone grafting has been frequently employed for the closure of bone defects at the jaw cleft site. Since the related surgical procedures are quite invasive for patients, it is of great importance to develop a new less invasive technique. The aim of this study was to examine bone regeneration with mesenchyme stem cells (MSCs) for the treatment of bone defect in artificially created jaw cleft in dogs. Materials and Methods. A bone defect was prepared bilaterally in the upper incisor regions of beagle dogs. MSCs derived from iliac bone marrow were cultured and transplanted with carbonated hydroxyapatite (CAP) particles into the bone defect area. The bone regeneration was evaluated by standardized occlusal X-ray examination and histological observation. Results. Six months after the transplantation, perfect closure of the jaw cleft was achieved on the experimental side. The X-ray and histological examination revealed that the regenerated bone on the experimental side was almost equivalent to the original bone adjoining the jaw cleft. Conclusion. It was suggested that the application of MSCs with CAP particles can become a new treatment modality for bone regeneration for CLP patients.

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References

Linton J, Sohn B, Yook J, Le Geros R . Effects of calcium phosphate ceramic bone graft materials on permanent teeth eruption in beagles. Cleft Palate Craniofac J. 2002; 39(2):197-207. DOI: 10.1597/1545-1569_2002_039_0197_eocpcb_2.0.co_2. View

Chin M, Ng T, Tom W, Carstens M . Repair of alveolar clefts with recombinant human bone morphogenetic protein (rhBMP-2) in patients with clefts. J Craniofac Surg. 2005; 16(5):778-89. DOI: 10.1097/01.scs.0000166802.49021.01. View

Natsume N, Suzuki T, Kawai T . The prevalence of cleft lip and plate in Japanese. Br J Oral Maxillofac Surg. 1988; 26(3):232-6. DOI: 10.1016/0266-4356(88)90168-4. View

Feinberg S, Vitt M . Effect of calcium phosphate ceramic implants on tooth eruption. J Oral Maxillofac Surg. 1988; 46(2):124-7. DOI: 10.1016/0278-2391(88)90263-7. View

Imanishi Y, Miyagawa S, Kitagawa-Sakakida S, Taketani S, Sekiya N, Sawa Y . Impact of synovial membrane-derived stem cell transplantation in a rat model of myocardial infarction. J Artif Organs. 2009; 12(3):187-93. DOI: 10.1007/s10047-009-0465-4. View

BERGLAND O, Semb G, Abyholm F . Elimination of the residual alveolar cleft by secondary bone grafting and subsequent orthodontic treatment. Cleft Palate J. 1986; 23(3):175-205. View

Pittenger M, Mackay A, Beck S, Jaiswal R, Douglas R, Mosca J . Multilineage potential of adult human mesenchymal stem cells. Science. 1999; 284(5411):143-7. DOI: 10.1126/science.284.5411.143. View

Hossain M, Kyomen S, Tanne K . Biologic responses of autogenous bone and beta-tricalcium phosphate ceramics transplanted into bone defects to orthodontic forces. Cleft Palate Craniofac J. 1996; 33(4):277-83. DOI: 10.1597/1545-1569_1996_033_0277_broaba_2.3.co_2. View

Hibi H, Yamada Y, Ueda M, Endo Y . Alveolar cleft osteoplasty using tissue-engineered osteogenic material. Int J Oral Maxillofac Surg. 2006; 35(6):551-5. DOI: 10.1016/j.ijom.2005.12.007. View

10.

Enemark H, Sindet-Pedersen S, Bundgaard M . Long-term results after secondary bone grafting of alveolar clefts. J Oral Maxillofac Surg. 1987; 45(11):913-9. DOI: 10.1016/0278-2391(87)90439-3. View

11.

Schultz R . Cleft palate fistula repair. Improved results by the addition of bone. J Craniomaxillofac Surg. 1989; 17 Suppl 1:34-6. DOI: 10.1016/s1010-5182(89)80038-1. View

12.

Vignery A, Baron R . Dynamic histomorphometry of alveolar bone remodeling in the adult rat. Anat Rec. 1980; 196(2):191-200. DOI: 10.1002/ar.1091960210. View

13.

Boyne P, Sands N . Secondary bone grafting of residual alveolar and palatal clefts. J Oral Surg. 1972; 30(2):87-92. View

14.

Zhang W, Yan Q, Zeng Y, Zhang X, Xiong Y, Wang J . Implantation of adult bone marrow-derived mesenchymal stem cells transfected with the neurotrophin-3 gene and pretreated with retinoic acid in completely transected spinal cord. Brain Res. 2010; 1359:256-71. DOI: 10.1016/j.brainres.2010.08.072. View

15.

Hosoyama M . [Changes in the microvascular pattern of the periodontium in an experimental tooth movement]. Nihon Kyosei Shika Gakkai Zasshi. 1989; 48(4):425-42. View

16.

Kagiwada H, Yashiki T, Ohshima A, Tadokoro M, Nagaya N, Ohgushi H . Human mesenchymal stem cells as a stable source of VEGF-producing cells. J Tissue Eng Regen Med. 2008; 2(4):184-9. DOI: 10.1002/term.79. View

17.

Laco F, Kun M, Weber H, Ramakrishna S, Chan C . The dose effect of human bone marrow-derived mesenchymal stem cells on epidermal development in organotypic co-culture. J Dermatol Sci. 2009; 55(3):150-60. DOI: 10.1016/j.jdermsci.2009.05.009. View

18.

Gimbel M, Ashley R, Sisodia M, Gabbay J, Wasson K, Heller J . Repair of alveolar cleft defects: reduced morbidity with bone marrow stem cells in a resorbable matrix. J Craniofac Surg. 2007; 18(4):895-901. DOI: 10.1097/scs.0b013e3180a771af. View

19.

Tanimoto K, Yanagida T, Tanne K . Orthodontic treatment with tooth transplantation for patients with cleft lip and palate. Cleft Palate Craniofac J. 2010; 47(5):499-506. DOI: 10.1597/08-134. View