CK/CK-MB Ratio As an Indirect Predictor for Survival in Polytraumatized Patients

Overview

Journal Wien Klin Wochenschr

Publisher Springer

Specialty General Medicine

Date 2012 Apr 25

PMID 22527818

Citations 1

Authors

Florian M Kovar

Silke Aldrian

Georg Endler

Vilmos Vecsei

Stefan Hajdu

Thomas Heinz

Oswald F Wagner

Affiliations

Soon will be listed here.

Abstract

Background: Accurate assessment of injury severity is critical for decision making related to the prevention, triage, and treatment of several injured patients. Early estimation of mortality risk of critically injured patients is mandatory for adequate therapeutic strategies. Current risk stratification relies on clinical diagnosis and scoring systems. In our study, we hypothesized whether a simple laboratory test, the CK/CK-MB ratio, could help improving risk prediction in severely traumatized patients.

Methods: In a 9-year period, 328 nonselected trauma patients were included in our retrospective study at a Level I Trauma Center up to September 2002. Data for this study were obtained from our computerized trauma database, established in September 1992.

Results: In our study population, we could show a negative correlation between Injury Severity Score (ISS) and leukocytes. A positive correlation was detected for liver enzymes and CK-MB. The correlation between ISS and Na(+) was significant. No correlation between ISS, K(+), and Hb/Ht could be observed. Exitus was associated with ISS, alteration in thrombocytes, CK, CK-MB, CRP, Crea, and Na(+).

Conclusion: In our study population, CK-MB levels showed a significant correlation with overall surveillance in polytraumatized patients. In our opinion, this might suggest that CK-MB levels could be taken as an indirect predictor for survival. Our findings need to be proven in further prospective clinical trials.

Citing Articles

Prognostic value of creatine kinase (CK)-MB to total-CK ratio in colorectal cancer patients after curative resection.

Rao L, Xu P, Zhang G, Zu R, Luo Y, Zhang K BMC Cancer. 2024; 24(1):543.

PMID: 38684978 PMC: 11059638. DOI: 10.1186/s12885-024-12307-5.

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