Updated Height- and Creatinine-based Equation and Its Validation for Estimation of Glomerular Filtration Rate in Children from Developing Countries

Background: Since the original Schwartz formula overestimates glomerular filtration rate (GFR), it is proposed that the constant (k) that accounts for the method of creatinine estimation be derived locally. We derived a new k for height (cm)/serum creatinine (mg/dl) (ht/scr) equation by regression analysis.

Methods: In a cross-sectional observational study, 197 children (2-18 years) with chronic kidney disease (CKD), who underwent reference GFR measurement by plasma clearance of diethylenetriamine pentaacetic acid (dGFR) at a tertiary care hospital, formed the index dataset for deriving the prediction equations for estimating GFR. Serum creatinine was estimated by the kinetic Jaffe method. The prediction equations were validated on a separate cohort of 225 children with CKD.

Results: The median creatinine was 0.7 mg/dl and dGFR was 80.5 (interquartile range 18.1-137.5) ml/min/1.73 m(2). The new k (regression coefficient of height/creatinine) was 0.42 (R(2) = 0.61) and the updated equation was GFR = 0.42 × (ht/scr). Addition of age and mid-arm circumference (MAC) to this equation improved R (2) to 62.3%. Based on the above parameters, the new equation for estimating GFR was GFR (ml/min/1.73 m(2)) = 0.257 × [ht/scr](0.95) × [age (year)](-0.19) × [MAC (cm)](0.397). The two equations performed comparably, with a mean bias <2 ml/min/1.73 m(2). The updated ht/scr equation yielded 74% and 24% estimated GFR values that were within 30% and 10% of the measured dGFR, respectively.

Conclusions: The updated equation, with a k value of 0.42, provides a reasonably accurate bedside estimate of GFR in children in countries where creatinine is estimated by the kinetic Jaffe method.