Hippo Signalling in the G2/M Cell Cycle Phase: Lessons Learned from the Yeast MEN and SIN Pathways

Overview

Journal Semin Cell Dev Biol

Specialties Cell Biology
Reproductive Medicine

Date 2012 Apr 25

PMID 22525225

Citations 51

Authors

Alexander Hergovich

Brian A Hemmings

Affiliations

Soon will be listed here.

Abstract

Over the past decade Hippo kinase signalling has been established as an essential tumour suppressor pathway controlling tissue growth in flies and mammals. All members of the Hippo core signalling cassette are conserved from yeast to humans, whereby the yeast analogues of Hippo, Mats and Lats are central components of the mitotic exit network and septation initiation network in budding and fission yeast, respectively. Here, we discuss how far core Hippo signalling components in Drosophila melanogaster and mammals have reported similar mitotic functions as already established for their highly conserved yeast counterparts.

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