Medial Temporal Atrophy and Memory Dysfunction in Poststroke Cognitive Impairment-no Dementia

Overview

Journal J Clin Neurol

Specialty Neurology

Date 2012 Apr 24

PMID 22523512

Citations 7

Authors

Beom Joon Kim

Mi-Young Oh

Myung Suk Jang

Moon-Ku Han

Jisung Lee

Juneyoung Lee

Yeonwook Kang

Kyung-Ho Yu

Byung-Chul Lee

SangYun Kim

Byung-Woo Yoon

Hee-Joon Bae

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: It was recently reported that the prevalence of poststroke memory dysfunction might be higher than previously thought. Stroke may exist concomitantly with underlying Alzheimer's disease (AD), and so we determined whether post-stroke memory dysfunction indicates manifestation of underlying subclinical AD.

Methods: Of 1201 patients in a prospective cognitive assessment database, we enrolled subjects with poststroke amnestic vascular cognitive impairment-no dementia (aVCIND; n=48), poststroke nonamnestic vascular cognitive impairment-no dementia (naVCIND; n=50), and nonstroke amnestic mild cognitive impairment (aMCI; n=65). All subjects had cognitive deficits, but did not meet the criteria for dementia. A standardized neuropsychological test battery and magnetic resonance imaging were performed at least 90 days after the index stroke (mean, 473 days). Visual assessment of medial temporal atrophy (MTA) was used as a measure of underlying AD pathology.

Results: The MTA score was significantly lower in the naVCIND group (0.64±0.85, mean±SD) than in the aVCIND (1.10±1.08) and aMCI (1.45±1.13; p<0.01) groups. Multivariable ordinal logistic regression analysis revealed that compared with naVCIND, aVCIND [odds ratio (OR)=2.69; 95% confidence interval (CI)=1.21-5.99] and aMCI (OR=5.20; 95% CI=2.41-11.23) were significantly associated with increasing severity of MTA.

Conclusions: Our findings show that compared with poststroke naVCIND, the odds of having more-severe MTA were increased for poststroke aVCIND and nonstroke aMCI.

Citing Articles

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References

Scheltens P, Leys D, Barkhof F, Huglo D, Weinstein H, Vermersch P . Atrophy of medial temporal lobes on MRI in "probable" Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates. J Neurol Neurosurg Psychiatry. 1992; 55(10):967-72. PMC: 1015202. DOI: 10.1136/jnnp.55.10.967. View

Kavirajan H, Schneider L . Efficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia: a meta-analysis of randomised controlled trials. Lancet Neurol. 2007; 6(9):782-92. DOI: 10.1016/S1474-4422(07)70195-3. View

Selden N, Gitelman D, Parrish T, Mesulam M . Trajectories of cholinergic pathways within the cerebral hemispheres of the human brain. Brain. 1999; 121 ( Pt 12):2249-57. DOI: 10.1093/brain/121.12.2249. View

Erkinjuntti T, Inzitari D, Pantoni L, Wallin A, Scheltens P, Rockwood K . Limitations of clinical criteria for the diagnosis of vascular dementia in clinical trials. Is a focus on subcortical vascular dementia a solution?. Ann N Y Acad Sci. 2000; 903:262-72. DOI: 10.1111/j.1749-6632.2000.tb06376.x. View

Zekry D . Is it possible to treat vascular dementia?. Front Neurol Neurosci. 2009; 24:95-106. DOI: 10.1159/000197888. View

Iadecola C . Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat Rev Neurosci. 2004; 5(5):347-60. DOI: 10.1038/nrn1387. View

den Heijer T, Vermeer S, van Dijk E, Prins N, Koudstaal P, Hofman A . Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI. Diabetologia. 2003; 46(12):1604-10. DOI: 10.1007/s00125-003-1235-0. View

Hachinski V, Iadecola C, Petersen R, Breteler M, Nyenhuis D, Black S . National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards. Stroke. 2006; 37(9):2220-41. DOI: 10.1161/01.STR.0000237236.88823.47. View

Korf E, Wahlund L, Visser P, Scheltens P . Medial temporal lobe atrophy on MRI predicts dementia in patients with mild cognitive impairment. Neurology. 2004; 63(1):94-100. DOI: 10.1212/01.wnl.0000133114.92694.93. View

10.

Wahlund L, Julin P, Johansson S, Scheltens P . Visual rating and volumetry of the medial temporal lobe on magnetic resonance imaging in dementia: a comparative study. J Neurol Neurosurg Psychiatry. 2000; 69(5):630-5. PMC: 1763427. DOI: 10.1136/jnnp.69.5.630. View

11.

Jokinen H, Kalska H, Ylikoski R, Hietanen M, Mantyla R, Pohjasvaara T . Medial temporal lobe atrophy and memory deficits in elderly stroke patients. Eur J Neurol. 2005; 11(12):825-32. DOI: 10.1111/j.1468-1331.2004.00870.x. View

12.

Scheltens P, Launer L, Barkhof F, Weinstein H, van Gool W . Visual assessment of medial temporal lobe atrophy on magnetic resonance imaging: interobserver reliability. J Neurol. 1995; 242(9):557-60. DOI: 10.1007/BF00868807. View

13.

Kalaria R . The role of cerebral ischemia in Alzheimer's disease. Neurobiol Aging. 2000; 21(2):321-30. DOI: 10.1016/s0197-4580(00)00125-1. View

14.

Roman G, Kalaria R . Vascular determinants of cholinergic deficits in Alzheimer disease and vascular dementia. Neurobiol Aging. 2005; 27(12):1769-85. DOI: 10.1016/j.neurobiolaging.2005.10.004. View

15.

van der Werf Y, Scheltens P, Lindeboom J, Witter M, Uylings H, Jolles J . Deficits of memory, executive functioning and attention following infarction in the thalamus; a study of 22 cases with localised lesions. Neuropsychologia. 2003; 41(10):1330-44. DOI: 10.1016/s0028-3932(03)00059-9. View

16.

Snaphaan L, de Leeuw F . Poststroke memory function in nondemented patients: a systematic review on frequency and neuroimaging correlates. Stroke. 2006; 38(1):198-203. DOI: 10.1161/01.STR.0000251842.34322.8f. View

17.

DeCarli C, Frisoni G, Clark C, Harvey D, Grundman M, Petersen R . Qualitative estimates of medial temporal atrophy as a predictor of progression from mild cognitive impairment to dementia. Arch Neurol. 2007; 64(1):108-15. DOI: 10.1001/archneur.64.1.108. View

18.

Niwa K, Kazama K, Younkin L, Younkin S, Carlson G, Iadecola C . Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein. Am J Physiol Heart Circ Physiol. 2002; 283(1):H315-23. DOI: 10.1152/ajpheart.00022.2002. View

19.

Rockwood K, Wentzel C, Hachinski V, Hogan D, Macknight C, McDowell I . Prevalence and outcomes of vascular cognitive impairment. Vascular Cognitive Impairment Investigators of the Canadian Study of Health and Aging. Neurology. 2000; 54(2):447-51. DOI: 10.1212/wnl.54.2.447. View

20.

Moorhouse P, Song X, Rockwood K, Black S, Kertesz A, Gauthier S . Executive dysfunction in vascular cognitive impairment in the consortium to investigate vascular impairment of cognition study. J Neurol Sci. 2009; 288(1-2):142-6. DOI: 10.1016/j.jns.2009.09.017. View