Allele Losses on Chromosome 17 in Human Epithelial Ovarian Carcinoma

Overview

Journal Oncogene

Specialties Molecular Biology
Oncology

Date 1990 Oct 1

PMID 2250917

Citations 30

Authors

D M Eccles

G Cranston

C M Steel

Y Nakamura

R C Leonard

Affiliations

Soon will be listed here.

Abstract

16 epithelial ovarian carcinomas (12 serous, 2 mucinous and 2 endometrioid) and 2 benign ovarian adenomas were studied using recombinant DNA technology to compare loci on chromosome 17 in germ-line and tumour DNA. Four polymorphic probes mapping to 17p and one mapping to 17q were used. There was a high frequency of allele loss on 17q/(77%) and a slightly lower frequency on 17p (69%). These findings probably indicate loss of tumour suppressor genes which are of fundamental importance in the genesis or progression of epithelial ovarian carcinomas.

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