PET/CT Imaging in Mouse Models of Myocardial Ischemia

Overview

Journal J Biomed Biotechnol

Specialty Biology

Date 2012 Apr 17

PMID 22505813

Citations 12

Authors

Sara Gargiulo

Adelaide Greco

Matteo Gramanzini

Maria Piera Petretta

Adele Ferro

Michele Larobina

Mariarosaria Panico

Arturo Brunetti

Alberto Cuocolo

Affiliations

Soon will be listed here.

Abstract

Different species have been used to reproduce myocardial infarction models but in the last years mice became the animals of choice for the analysis of several diseases, due to their short life cycle and the possibility of genetic manipulation. Many techniques are currently used for cardiovascular imaging in mice, including X-ray computed tomography (CT), high-resolution ultrasound, magnetic resonance imaging, and nuclear medicine procedures. Cardiac positron emission tomography (PET) allows to examine noninvasively, on a molecular level and with high sensitivity, regional changes in myocardial perfusion, metabolism, apoptosis, inflammation, and gene expression or to measure changes in anatomical and functional parameters in heart diseases. Currently hybrid PET/CT scanners for small laboratory animals are available, where CT adds high-resolution anatomical information. This paper reviews mouse models of myocardial infarction and discusses the applications of dedicated PET/CT systems technology, including animal preparation, anesthesia, radiotracers, and images postprocessing.

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