Jagged1 and Notch1 Help Edit M Cell Patterning in Peyer's Patch Follicle Epithelium

Overview

Journal Dev Comp Immunol

Specialty Allergy & Immunology

Date 2012 Apr 17

PMID 22504165

Citations 13

Authors

En-Hui Hsieh

David D Lo

Affiliations

Soon will be listed here.

Abstract

Mucosal epithelium M cells are dispersed across Peyer's patch follicle associated epithelium (PPFAE) with minimal clustering. Since Notch signaling can influence patterning in epithelia, we examined its influence on PPFAE M cell distribution. Conditional deletion of Notch1 in intestinal epithelium increased PPFAE M cells and also increased M cell clustering, implying a role for Notch in both M cell numbers and lateral inhibition. By contrast, conditional deletion of the ligand Jagged1 also increased M cell clustering, but with a paradoxical decrease in M cell density. In vitro, inhibition of Notch signaling reduced expression of an M cell associated gene CD137, consistent with cis-promoting effects on M cell development. Thus, Jagged1 may have a cis-promoting role in committed M cells, but a trans-inhibitory effect on neighboring cells. In sum, Jagged1-Notch signaling may edit the pattern of M cells across the PPFAE, which may help optimize mucosal immune surveillance.

Citing Articles

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activation in the Notch signaling pathway.

Nandagopal N, Santat L, Elowitz M Elife. 2019; 8.

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