MR Elastography in Renal Transplant Patients and Correlation with Renal Allograft Biopsy: a Feasibility Study

Overview

Journal Acad Radiol

Specialty Radiology

Date 2012 Apr 17

PMID 22503893

Citations 43

Authors

Christine U Lee

James F Glockner

Kevin J Glaser

Meng Yin

Jun Chen

Akira Kawashima

Bohyun Kim

Walter K Kremers

Richard L Ehman

James M Gloor

Affiliations

Soon will be listed here.

Abstract

Rationale And Objectives: Magnetic resonance elastography (MRE) images the propagation of mechanical shear waves in tissue and uses that information to generate quantitative measures of tissue stiffness. Hepatic MRE has been successfully performed in thousands of patients, with good correlation between histologic grade of fibrosis and tissue stiffness. There has been no prior investigation of the utility of MRE for the assessment of kidney transplants. The aims of this study were to prospectively evaluate the feasibility of MRE in a small group of kidney transplant recipients and to correlate the measured magnetic resonance elastographic stiffness values with biopsy-proven histopathologic fibrosis.

Materials And Methods: MRE of renal transplants was performed in 11 patients returning for protocol allograft biopsies. Calculated tissue stiffness values were compared to histologic degree of fibrosis in nine of the 11 patients.

Results: The mean stiffness of two patients with moderate interstitial fibrosis was higher than the mean of six patients with mild interstitial fibrosis, but not significantly so (90 Hz, P = .12; 120 Hz, P = .17; 150 Hz, P = .26). The mean stiffness of the two patients with moderate interstitial fibrosis was slightly greater than the mean of one patient with no significant interstitial fibrosis at 90 Hz (P = .78) and slightly less at 120 and 150 Hz (P = .88 and P = .76). The mean stiffness of the six patients with mild interstitial fibrosis did not differ significantly from that of the one patient with no interstitial fibrosis (90 Hz, P = .35; 120 Hz, P = .22; 150 Hz, P = .16).

Conclusions: Preliminary results demonstrate feasibility and support known multifactorial influences on renal stiffness.

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