Chronic Rhinitis in HTLV-1 Carriers: a Histopathologic Study

Overview

Journal Braz J Otorhinolaryngol

Specialty Otorhinolaryngology

Date 2012 Apr 14

PMID 22499368

Citations 1

Authors

Fernando P Gaspar Sobrinho

Adelmir Souza-Machado

Alvaro A Cruz

Helio A Lessa

Eduardo A Ramos

Affiliations

Soon will be listed here.

Abstract

Unlabelled: The nasal histopathology of HTLV-1 carriers with chronic rhinitis is unknown.

Objective: To describe the histopathological features of HTLV-1 carriers with chronic rhinitis.

Materials And Methods: Biopsies of nasal mucosa of ten HTLV-1 carriers with chronic rhinitis (eight patients with allergic rhinitis and two patients with non-allergic rhinitis) were studied using a light microscope. Samples from ten patients with allergic rhinitis not infected with HTLV-1 were used as controls.

Results: Subepithelial fibrosis was more pronounced in patients with allergic rhinitis infected with HTLV-1 (p=0.01), while the basement membrane thickness was greater in controls (p=0.03). There was a trend towards less eosinophilia and edema among those infected with HTLV-1, without statistical significance (p=0.2). For the lymphocytic infiltrate, there was no difference between infected and not infected patients with allergic rhinitis (p=1.0). Subepithelial fibrosis associated to moderate or small number of lymphocytes were found in the two HTLV-1 carriers with non-allergic rhinitis.

Conclusions: This study suggests HTLV-1 may modify the histopathology of allergic rhinitis, especially by promoting subepithelial fibrosis, and may be related to chronic non-allergic rhinitis with lymphocytic infiltrate.

Citing Articles

Current State of Therapeutics for HTLV-1.

Wang T, Hirons A, Doerflinger M, Morris K, Ledger S, Purcell D Viruses. 2024; 16(10).

PMID: 39459949 PMC: 11512412. DOI: 10.3390/v16101616.

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