Asymmetric Bioreduction of Activated Alkenes to Industrially Relevant Optically Active Compounds

Overview

Journal J Biotechnol

Specialties Biomedical Engineering
Biotechnology

Date 2012 Apr 14

PMID 22498437

Citations 26

Authors

Christoph K Winkler

Gabor Tasnadi

Dorina Clay

Melanie Hall

Kurt Faber

Affiliations

Soon will be listed here.

Abstract

Ene-reductases from the 'Old Yellow Enzyme' family of flavoproteins catalyze the asymmetric reduction of various α,β-unsaturated compounds at the expense of a nicotinamide cofactor. They have been applied to the synthesis of valuable enantiopure products, including chiral building blocks with broad industrial applications, terpenoids, amino acid derivatives and fragrances. The combination of these highly stereoselective biocatalysts with a cofactor recycling system has allowed the development of cost-effective methods for the generation of optically active molecules, which is strengthened by the availability of stereo-complementary enzyme homologues.

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