The Ancient and Evolving Roles of Cohesin in Gene Expression and DNA Repair

Overview

Journal Curr Biol

Publisher Cell Press

Specialty Biology

Date 2012 Apr 14

PMID 22497943

Citations 98

Authors

Dale Dorsett

Lena Strom

Affiliations

Soon will be listed here.

Abstract

The cohesin complex, named for its key role in sister chromatid cohesion, also plays critical roles in gene regulation and DNA repair. It performs all three functions in single cell eukaryotes such as yeasts, and in higher organisms such as man. Minor disruption of cohesin function has significant consequences for human development, even in the absence of measurable effects on chromatid cohesion or chromosome segregation. Here we survey the roles of cohesin in gene regulation and DNA repair, and how these functions vary from yeast to man.

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