Axon Degeneration: Where the Wlds Things Are

Overview

Journal Curr Biol

Publisher Cell Press

Specialty Biology

Date 2012 Apr 14

PMID 22497934

Citations 14

Authors

Jack T Wang

Ben A Barres

Affiliations

Soon will be listed here.

Abstract

Expression of the Wld(s) protein significantly delays axon degeneration in injuries and diseases, but the mechanism for this protection is unknown. Two recent reports present evidence that axonal mitochondria are required for Wld(S)-mediated axon protection.

Citing Articles

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Axonal spheroids in neurodegeneration.

Yong Y, Hunter-Chang S, Stepanova E, Deppmann C Mol Cell Neurosci. 2021; 117:103679.

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Traumatic Brain Injury: Ultrastructural Features in Neuronal Ferroptosis, Glial Cell Activation and Polarization, and Blood-Brain Barrier Breakdown.

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Commonalities of optic nerve injury and glaucoma-induced neurodegeneration: Insights from transcriptome-wide studies.

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Proteomic profiling of neuronal mitochondria reveals modulators of synaptic architecture.

Graham L, Eaton S, Brunton P, Atrih A, Smith C, Lamont D Mol Neurodegener. 2017; 12(1):77.

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