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Genotoxicity Studies Performed in the Ecuadorian Population

Overview
Journal Mol Biol Int
Publisher Hindawi
Specialty Molecular Biology
Date 2012 Apr 13
PMID 22496977
Citations 3
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Abstract

Genotoxicity studies in Ecuador have been carried out during the past two decades. The focuses of the research were mainly the area of environmental issues, where the populations have been accidentally exposed to contaminants and the area of occupational exposure of individuals at the workplace. This paper includes studies carried out in the population of the Amazon region, a zone known for its rich biodiversity as well as for the ecological damage caused by oil spills and chemical sprayings whose consequences continue to be controversial. Additionally, we show the results of studies comprised of individuals occupationally exposed to toxic agents in two very different settings: flower plantation workers exposed to pesticide mixtures and X-ray exposure of hospital workers. The results from these studies confirm that genotoxicity studies can help evaluate current conditions and prevent further damage in the populations exposed to contaminants. As such, they are evidence of the need for biomonitoring employers at risk, stricter law enforcement regarding the use of pesticides, and increasingly conscientious oil extraction activities.

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References
1.
Tsatsakis A, Zafiropoulos A, Tzatzarakis M, Tzanakakis G, Kafatos A . Relation of PON1 and CYP1A1 genetic polymorphisms to clinical findings in a cross-sectional study of a Greek rural population professionally exposed to pesticides. Toxicol Lett. 2008; 186(1):66-72. DOI: 10.1016/j.toxlet.2008.10.018. View

2.
Lushchak O, Kubrak O, Storey J, Storey K, Lushchak V . Low toxic herbicide Roundup induces mild oxidative stress in goldfish tissues. Chemosphere. 2009; 76(7):932-7. DOI: 10.1016/j.chemosphere.2009.04.045. View

3.
Goode E, Ulrich C, Potter J . Polymorphisms in DNA repair genes and associations with cancer risk. Cancer Epidemiol Biomarkers Prev. 2002; 11(12):1513-30. View

4.
El-Shenawy N . Oxidative stress responses of rats exposed to Roundup and its active ingredient glyphosate. Environ Toxicol Pharmacol. 2011; 28(3):379-85. DOI: 10.1016/j.etap.2009.06.001. View

5.
Kadouri L, Kote-Jarai Z, Hubert A, Baras M, Abeliovich D, Hamburger T . Glutathione-S-transferase M1, T1 and P1 polymorphisms, and breast cancer risk, in BRCA1/2 mutation carriers. Br J Cancer. 2008; 98(12):2006-10. PMC: 2441947. DOI: 10.1038/sj.bjc.6604394. View