Double the Keys, Double the Control: Coupled Phosphorylation Sites Provide Novel Molecular Targets for Precise Control of Ion Channel Function. Focus on "Differential Regulation of a CLC Anion Channel by SPAK Kinase Ortholog-mediated Multisite...

Overview

Journal Am J Physiol Cell Physiol

Publisher American Physiological Society

Specialties Cell Biology
Physiology

Date 2012 Apr 13

PMID 22496246

Citations 1

Authors

Dayue Darrel Duan

Guangyu Wang

Affiliations

Soon will be listed here.

Citing Articles

Differential regulation of a CLC anion channel by SPAK kinase ortholog-mediated multisite phosphorylation.

Miyazaki H, Strange K Am J Physiol Cell Physiol. 2012; 302(12):C1702-12.

PMID: 22357738 PMC: 3378076. DOI: 10.1152/ajpcell.00419.2011.

References

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Thomson M, Gunawardena J . Unlimited multistability in multisite phosphorylation systems. Nature. 2009; 460(7252):274-7. PMC: 2859978. DOI: 10.1038/nature08102. View

Marjan Varedi K S, Ventura A, Merajver S, Lin X . Multisite phosphorylation provides an effective and flexible mechanism for switch-like protein degradation. PLoS One. 2010; 5(12):e14029. PMC: 3001445. DOI: 10.1371/journal.pone.0014029. View

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Miyazaki H, Strange K . Differential regulation of a CLC anion channel by SPAK kinase ortholog-mediated multisite phosphorylation. Am J Physiol Cell Physiol. 2012; 302(12):C1702-12. PMC: 3378076. DOI: 10.1152/ajpcell.00419.2011. View

Rutledge E, Denton J, Strange K . Cell cycle- and swelling-induced activation of a Caenorhabditis elegans ClC channel is mediated by CeGLC-7alpha/beta phosphatases. J Cell Biol. 2002; 158(3):435-44. PMC: 2173826. DOI: 10.1083/jcb.200204142. View

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Furukawa T, Ogura T, Zheng Y, Tsuchiya H, Nakaya H, Katayama Y . Phosphorylation and functional regulation of ClC-2 chloride channels expressed in Xenopus oocytes by M cyclin-dependent protein kinase. J Physiol. 2002; 540(Pt 3):883-93. PMC: 2290285. DOI: 10.1113/jphysiol.2001.016188. View