Development of Leishmania (Leishmania) Infantum Chagasi in Its Natural Sandfly Vector Lutzomyia Longipalpis

Overview

Journal Am J Trop Med Hyg

Specialty Tropical Medicine

Date 2012 Apr 12

PMID 22492144

Citations 13

Authors

Vanessa C Freitas

Klivia P Parreiras

Ana Paula M Duarte

Nagila F C Secundino

Paulo F P Pimenta

Affiliations

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Abstract

We analyzed the development of Leishmania (Leishmania) infantum chagasi in its natural sandfly vector Lutzomyia longipalpis. In addition, we compared sandfly infections initiated with axenic amastigotes or promastigotes. Our data showed no important difference between Lu. longipalpis infection rates resulting from either type of infections. Furthermore, development of infection was equivalent in both cases. All promastigote forms were found inside the sandfly and, after blood digestion, most of the population consisted of procyclics and nectomonads. A low percentage of metacyclic forms was coincident with a high number of nectomonads during late stages of infection, but which form gives rise to metacyclic forms in L. infantum chagasi is unknown. These results also show that the promastigote infection model, at least for this situation, is suitable for obtaining of infected sandflies because it is easier and less laborious.

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