A New Player in the Puzzle of Filovirus Entry

Overview

Journal Nat Rev Microbiol

Specialties Infectious Diseases
Microbiology

Date 2012 Apr 12

PMID 22491356

Citations 47

Authors

Judith M White

Kathryn L Schornberg

Affiliations

Soon will be listed here.

Abstract

Viruses of the genera Ebolavirus and Marburgvirus are filoviruses that cause haemorrhagic fever in primates, with extremely high fatality rates. Studies have focused on elucidating how these viruses enter host cells, with the aim of developing therapeutics. The ebolavirus glycoprotein has been found to play key parts in all steps of entry. Furthermore, recent studies have identified Niemann-Pick C1 (NPC1), a protein that resides deep in the endocytic pathway, as an important host factor in this process.

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